Cytochrome P4501A1 polymorphisms in the Amerindian and Mestizo populations of Mexico

Cell Biochemistry and Function
J M FragosoG Vargas-Alarcon

Abstract

Several polymorphisms in the CYP1A1 locus have been identified and their genotypes appear to exhibit population frequencies that depend on ethnicity. We studied two CYP1A1 polymorphic sites (position 4889 and 6235) in a group of 212 unrelated healthy individuals belonging to three different Mexican populations (106 Mexican Mestizos, 52 Teenek and 54 Mayos). Comparison among Mexican populations showed increased frequency of the *Ile allele (A on position 4889) in Mexican Mestizos when compared to Amerindians (p < 0.05). The analysis of position 6235 showed increased frequencies of *m2 (C in this position) allele in Teenek when compared to Mestizos and Mayos (p < 0.05) and of *m2/*m2 genotype when compared to Mestizos (p < 0.05). Amerindian populations (from Mexico and South America) presented the lowest frequencies of *Ile (position 4889) and *m1 (position 6235) alleles, however these frequencies vary according to the ethnic group studied. Mexican Amerindian groups together with other South Amerindian populations showed the highest frequencies for *Val at position 4889 and the *m2 allele at position 6235. The present study corroborates the high frequencies of*Val and *m2 alleles in the Amerindian populations and detects some dif...Continue Reading

References

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Citations

May 22, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Teresa Juárez-CedilloGilberto Vargas-Alarcón
Feb 2, 2018·Journal of Personalized Medicine·Lindsay M HendersonKenneth E Thummel
Apr 17, 2008·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Han-Chun ChenYan-Fei Cao
Apr 7, 2006·Cell Biochemistry and Function·DaCheng HaoLing Yang
Oct 23, 2013·Drug Metabolism and Drug Interactions·Martha Sosa-Macías, Adrián Llerena
May 19, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ryan M SwinneyGail E Tomlinson

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