Abstract
Cytochrome P4502E1 (CYP2E1) activates carcinogenic N-nitrosamines, benzene, urethane and other low molecular weight compounds. This enzyme is also inducible by ethanol, and metabolizes alcohol. A restriction fragment length polymorphism (RFLP) using the Rsa I restriction enzyme has been identified in the CYP2E1 transcription regulatory region; recent studies suggest that this polymorphism may affect gene expression. We investigated the frequency of the Rsa I RFLP in a Japanese population in relation to gastric cancer and liver disease susceptibility. The frequency of this polymorphism was determined in 150 gastric cancer, 16 hepatocellular cancer, 48 liver cirrhosis and 203 benign gastric disease (controls) patients. This preliminary study shows no association of the specific genotype with gastric cancer in all subjects (odds ratio = 1.04, 95% CI = 0.74-3.08 for the heterozygote and 0.57, 95% CI = 0.22-1.50 for the homozygous rare allele, respectively). To further confirm this lack of association, an age and gender matched case-control study should be performed. Separately, there was no association of the Rsa I RFLP with hepatocellular carcinoma (p = 0.911), but there was a suggested difference between the non-viral associated ...Continue Reading
Citations
Jun 20, 2007·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Gotaro MasudaTakashi Tajiri
Apr 25, 2003·Experimental and Molecular Pathology·Tamiko KonishiYu-Jui Yvonne Wan
Feb 13, 2004·Drug Discovery Today·Andrej BugrimYuri Nikolsky
May 13, 1998·Gut·I D NortonJ S Wilson
Nov 10, 2012·PloS One·Wenlei ZhuoZhengtang Chen
Apr 23, 2004·Pharmacogenomics·David F V Lewis
Jul 1, 2004·Pharmacogenetics·Su Young KimHai Won Chung
Sep 3, 2005·Molecular Diagnosis : a Journal Devoted to the Understanding of Human Disease Through the Clinical Application of Molecular Biology·Yoshiko AtsutaAkiko Tamakoshi
Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Carlos A GonzálezGabriel Capellá
Jun 5, 2004·Toxicology Letters·Thomas NeuhausThomas Brüning
Nov 7, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Mridul MalakarKanwar Narain
Dec 19, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Zhong TianChen-Liang Zhang
Oct 4, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Juei-Chuan C Kang-SickelLeena A Nylander-French
Nov 4, 2000·International Journal of Cancer. Journal International Du Cancer·H ShenQ Wei
Nov 20, 1998·Cadernos de saúde pública·N Conforti-FroesW Au
Jan 16, 1999·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G SmithC R Wolf
Jun 1, 1995·Clinical Pharmacology and Therapeutics·R B Kim, D O'Shea
Oct 21, 2010·Alcoholism, Clinical and Experimental Research·Amy WebbKirk Wilhelmsen
Dec 1, 1996·Liver·J AgúndezJ Benítez
Apr 28, 2004·World Journal of Gastroenterology : WJG·Jucimara ColomboAna Elizabete Silva
Jul 23, 2004·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Konstantin V BalakinTatiana Nikolskaya
Jun 11, 2016·Molecular and Clinical Oncology·Ming-Xing ZhangXi-Lin Song
Aug 9, 2003·Journal of Medicinal Chemistry·Dmitry KorolevTatiana Nikolskaya