PMID: 9194522May 1, 1997Paper

Cytochromes P450 12: diversity of ACTH (cAMP)-dependent transcription of bovine steroid hydroxylase genes

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
M R Waterman, L J Bischof

Abstract

An essential role of ACTH is to assure that optimal steroidogenic capacity is maintained in the adrenal cortex throughout life. This is achieved by maintaining transcriptional pressure on the genes encoding the adrenocortical steroid hydroxylases via the second messenger, cAMP. Even though these genes respond coordinately to cAMP, it has been surprising to discover that each gene uses its own unique cAMP response system during this coordinate response. Thus, different cis elements and sets of transcription factors control the cAMP responsiveness of each different steroid hydroxylase gene. Although the physiological basis of this diversity in biochemical mechanisms of transcriptional regulation is not apparent, a portion of this signaling pathway is common to all of these genes. In particular, the action of cAMP-dependent protein kinase and an as yet uncharacterized cycloheximide-sensitive step are necessary for ACTH-mediated transcription of each gene. Biochemical characterization of these common steps in the ACTH-dependent signaling pathways is essential to an understanding of the maintenance of optimal steroidogenic capacity in the adrenal cortex.

Citations

Dec 31, 2002·The Journal of Biological Chemistry·Marion B Sewer, Michael R Waterman
Mar 27, 2012·Endocrine Journal·Juan ZhangLuyong Zhang
Oct 3, 2018·Communications Biology·Takashi BabaKen-Ichirou Morohashi
May 1, 2007·Expert Reviews in Molecular Medicine·João GonçalvesLuís Moura
May 5, 2000·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·D A LoweS E Alway
Jun 17, 2000·Endocrine Reviews·P C White, P W Speiser
Jun 13, 2009·Journal of Bioenergetics and Biomembranes·Attilio PingitoreGiuseppe Genchi
Oct 26, 1999·Biochemical and Biophysical Research Communications·C Dauphin-VillemantR Lafont
Feb 25, 2000·Molecular and Cellular Endocrinology·P LiakosG Defaye
Jul 20, 1999·Molecular and Cellular Endocrinology·W E Rainey
May 12, 2004·Molecular and Cellular Endocrinology·Mary H BassettWilliam E Rainey
May 24, 2005·Reproductive Toxicology·Jianfeng ChenXinru Wang

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