Cytochromes P450 as versatile biocatalysts

Journal of Biotechnology
Rita Bernhardt

Abstract

Cytochromes P450 are ubiquitously distributed enzymes, which were discovered about 50 years ago and which possess high complexity and display a broad field of activity. They are hemoproteins encoded by a superfamily of genes converting a broad variety of substrates and catalysing a variety of interesting chemical reactions. This enzyme family is involved in the biotransformation of drugs, the bioconversion of xenobiotics, the metabolism of chemical carcinogens, the biosynthesis of physiologically important compounds such as steroids, fatty acids, eicosanoids, fat-soluble vitamins, bile acids, the conversion of alkanes, terpenes, and aromatic compounds as well as the degradation of herbicides and insecticides. There is also a broad versatility of reactions catalysed by cytochromes P450 such as carbon hydroxylation, heteroatom oxygenation, dealkylation, epoxidation, aromatic hydroxylation, reduction, dehalogenation (Sono, M., Roach, M.P., Coulter, E.D., Dawson, J.H., 1996. Heme-containing oxygenases. Chem. Rev. 96, 2841-2888), (Werck-Reichhart, D., Feyereisen, R., 2000. Cytochromes P450: a success story. Genome Biol. 1 (REVIEWS3003)), (Bernhardt, R., 2004. Cytochrome P-450. Encyclopedia Biol. Chem. 1, 544-549), (Bernhardt, R., 20...Continue Reading

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Citations

Jul 16, 2008·Analytical and Bioanalytical Chemistry·Kersten S RabeChristof M Niemeyer
Dec 25, 2008·Applied Microbiology and Biotechnology·Nedeljka N Rosic
May 13, 2009·Applied Microbiology and Biotechnology·Marek J PecynaMartin Hofrichter
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Feb 24, 2010·Applied Microbiology and Biotechnology·Toshiki Furuya, Kuniki Kino
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