Cytocompatibility of PLA/Nano-HA composites for interface fixation

Artificial Cells, Nanomedicine, and Biotechnology
Weimin ZhuYanjun Zeng

Abstract

When preliminary tests have confirmed a nano-hydroxyapatite (Nano-HA) content of 20% of the polylactic acid (PLA) composite material of Nano-HA interface fixation material for biomechanical requirements, there is a need for further observation of its biocompatibility and clinical applications, to provide reference data. Preparation of Nano-HA content of 20% PLA composite Nano-HA bone substitute material and extract. The establishment of the negative control group (containing 10% fetal bovine serum in DMEM complete medium), experimental group (extract), the positive control group (mass concentration of 0.64% phenol), and a co-culture of rabbit bone marrow mesenchymal stem cells (rBMSC) and materials extraction liquid. Observation of the morphological changes in rBMSC in culture at time points of 3, 5, and 7 days, the use of the MTT assay, and determination of the relative growth in the above set of rBMSC in cell culture at 3, 5, and 7 days, to judge the material's cytotoxicity. With time, the absorbance value of the three groups of cells were significantly increased (P < 0.01). The relative growth of the rBMSCs in experimental group in the first 3, 5, and 7 days was 95.3%, 96.8% and 97.6%; the cytotoxicity was according to the n...Continue Reading

References

Jan 1, 1995·Journal of Biomaterials Science. Polymer Edition·M F Harmand
Jun 3, 2009·Journal of Materials Science. Materials in Medicine·Lie ShenMao Peng
Aug 21, 2013·Artificial Cells, Nanomedicine, and Biotechnology·Weimin ZhuYanjun Zeng
Dec 26, 2013·In Vitro Cellular & Developmental Biology. Animal·Weimin ZhuYanjun Zeng

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