Cytocompatibility studies of titania-doped calcium borosilicate bioactive glasses in-vitro

Materials Science & Engineering. C, Materials for Biological Applications
Rajkumar SamudralaBramanandam Manavathi

Abstract

The present study aims to elucidate the applications of Titania (TiO2) doped calcium borosilicate glass as a biocompatible material in regenerative orthopedic applications. In this context, we have examined the bioactivity of various concentrations of TiO2 doped glasses with the help of simulated body fluid (SBF). Cytocompatibility, cell proliferation, and protein expression studies revealed the potential candidature of TiO2 doped glasses on osteoblast cell lines (MG-63). We hypothesized that TiO2 doped calcium borosilicate glasses are most cytocompatible material for bone implants. Glasses with composition 31B2O3-20SiO2-24.5Na2O-(24.5-x) CaO- x TiO2 (x=0,0.5,1,2) have been prepared by the conventional melt-quenching technique. After immersion of glasses in the SBF, formation of hydroxyapatite layer on the surface was confirmed by X-ray Diffractometer (XRD), Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy-Energy Dispersive Spectroscopy (SEM-EDS) analysis. Significant change in the pH of the body fluid was observed with the addition of titania. Degradation test was performed as per the ISO 10993. The results showed that partial substitution of TiO2 with CaO negatively influenced bioactivity; it d...Continue Reading

Citations

Nov 20, 2020·Progress in Biomaterials·Srinath PalakurthyP Abdul Azeem
Nov 6, 2020··K. Venugopal ReddyPalakurthy Srinath

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Related Papers

ACS Applied Materials & Interfaces
V Sarath ChandraS Narayana Kalkura
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Sherief M Abo-NafRasha A Youness
Journal of Biomedical Materials Research
I Izquierdo-BarbaM Vallet-Regí
Journal of Biomedical Materials Research. Part B, Applied Biomaterials
Ammar Z AlshemaryZafer Evis
© 2022 Meta ULC. All rights reserved