Cytodifferentiation and developing neuronal circuitry in the human lateral geniculate nucleus

International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience
S Wadhwa, V Bijlani

Abstract

The developing neural substrate in dorsal lateral geniculate nucleus of human fetuses and premature, full-term and postnatal infants, has been analysed using rapid Golgi impregnation, computerized image analysis, electronmicroscopy, and immunocytochemical method for localization of gamma-aminobutyric acid. Nuclear and cytoplasmic neuronal maturation is observed to extend over the entire period studied. Axodendritic synapses, presumably of retinal origin, are occasionally seen at 13-14 fetal weeks. They become increasingly apparent at 18-19 weeks. Dendrodendritic contacts are visualized at 15 weeks. Cortical terminals and occasional triadic contacts are evident around 21 weeks. The inhibitory interneurons containing gamma-aminobutyric acid are present in small numbers at 15-16 weeks; their numerical density increases considerably at 17 weeks but decreases thereafter. The presence of gamma-aminobutyric acid containing nerve cells and synaptic triads is indicative of the formation of inhibitory circuitry. At 15-16 weeks neurons are mostly bipolar although different forms of multipolar cells may be seen. By 24 weeks the radiated and bitufted multipolar neurons, neurons with beaded dendrites and neurons with axon-like dendritic proc...Continue Reading

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Citations

Jun 8, 2013·Documenta Ophthalmologica. Advances in Ophthalmology·Rain G BosworthKaren R Dobkins
Nov 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A A KhanV Bijlani
May 4, 2001·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K E TaylorJ F Stein
Feb 3, 2015·Journal of Theoretical Biology·Ivan GrbatinićNebojša T Milošević
Sep 6, 2000·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K E Taylor, A J Richardson
Jul 1, 1991·The Journal of Comparative Neurology·J K Sutton, J K Brunso-Bechtold

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