PMID: 9428929Jan 16, 1998Paper

Cytodifferentiation of atypical adenomatous hyperplasia and bronchioloalveolar lung carcinoma: immunohistochemical and ultrastructural studies

Virchows Archiv : an International Journal of Pathology
H KitamuraM Kanisawa

Abstract

We used immunohistochemistry and electron microscopy to evaluate the differentiation of cells comprising atypical adenomatous hyperplasia (AAH; n = 26), early bronchioloalveolar lung carcinoma (BAC; n = 11), and overt BAC (n = 16), which are assumed to constitute a continuous spectrum of developmental steps of BAC. Surfactant apoprotein (SAP), a marker for type 2 alveolar cells, was expressed in cells from all the lesions of AAH, early BAC, and overt BAC. However, the proportion of SAP-positive cells decreased and their distribution became more heterogeneous with advancing lesion grade. Urine protein 1, which is identical to the Clara cell-specific 10 kDa protein, was expressed in 70% of overt BAC, whereas only 20% of early BAC showed weak reactivity and none of AAH lesions showed any reactivity at all. Ultrastructurally, type 2 alveolar cell differentiation was predominant among cells from AAH and early BAC. Our results suggest that precursor cells of BAC differentiate predominantly towards type 2 alveolar cells. Cells comprising overt BAC retain this differentiation phenotype, but to a reduced extent. In contrast, concomitantly with progression, cells with Clara cell differentiation emerge and their proportion increases. Such...Continue Reading

Citations

Sep 12, 2001·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·T YokoseA Ochiai
Nov 26, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Chikako TakezawaShosaku Abe
Jun 5, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Tatyana A ZhukovMelvyn S Tockman
Jul 23, 2003·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Takashi HiranoHarubumi Kato
Apr 18, 2001·Journal of Clinical Pathology·K M Kerr
Jul 7, 2007·Cancer·Madeline F VazquezDavid F Yankelevitz
Jan 7, 2000·The American Journal of Pathology·R J MasonJ M Shannon
Mar 10, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·M MoriA E Fraire
Oct 21, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Han ChangPinpin Lin
May 1, 2002·Respiratory Research·Alissa K GreenbergWilliam N Rom
May 6, 2003·Biochimica Et Biophysica Acta·Ziv Manasija RadisavljevicZiv Manasija-Radisavljevic

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