Cytogenetic aberrations in primary and recurrent fibrolamellar hepatocellular carcinoma detected by comparative genomic hybridization

American Journal of Clinical Pathology
L WilkensH Kreipe

Abstract

Fibrolamellar hepatocellular carcinoma (FLC) is a rare entity of hepatocellular carcinoma (HCC) not yet analyzed cytogenetically. By using comparative genomic hybridization (CGH), we looked for chromosome changes in 2 primary FLCs and a recurrent FLC with and without metastases. CGH revealed an amplification of 1q in 1 primary FLC. The other primary FLC and a metastasis revealed no changes. The recurrent FLC showed 18 aberrations, including 1q+, 2p+, 3p+, 3q+, 4p+, 4q+, 5p+, 5q+, 6q+, 8p+, 8q+, 9q+, 12p+, 12q+, 18p+, 18q+, Xp+, and Xq+. In 2 metastases, 9 and 10 aberrations were seen, including 1q+, 3p-, 3q-, 4q+, 5p+, 5q+, 8q+, 10p+, 10q+, Xp+, and Xq+. In 9 cases of other entities of HCC, a mean of 10.2 aberrations per case were detectable affecting 1q (7 cases), 4q (5), 5q (4), 6q (5), 8p (5), 8q (5), 9p (4), 9q (5), 16q (4), 17p (5), and 17q (4). Chromosomes 2p, 2q, 3p, 3q, 4p, 5p, 6p, 7p, 7q, 10q, 11p, 11q, 12p, 12q, 13q, 14q, 16p, 18p, 18q, 20p, 20q, and 21q were altered in up to 3 samples. Our findings indicate striking differences in the number of chromosomal imbalances in primary FLC and recurrent FLC, whereas imbalances seen in the recurrent FLC and the other entities of HCC were similar in number and chromosomes invo...Continue Reading

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Citations

Feb 22, 2014·AJR. American Journal of Roentgenology·Dhakshinamoorthy GaneshanKhaled Elsayes
Aug 15, 2014·Human Molecular Genetics·Lei XuJulien Sage
Apr 21, 2010·Proceedings of the National Academy of Sciences of the United States of America·Byoung Kwon YooDevanand Sarkar
Feb 12, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Perumal Vivekanandan, Michael Torbenson
Jan 1, 2012·Scientifica·Michael Torbenson
Jan 16, 2009·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·V ManiaciT Meyer
Mar 19, 2016·Pediatric Blood & Cancer·Kevin M RiggleKimberly J Riehle
Apr 19, 2002·Expert Review of Molecular Diagnostics·Ludwig WilkensHans Kreipe
May 28, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sanjay KakarLinda D Ferrell
Jul 30, 2009·The American Journal of Gastroenterology·Shu LiuLiang Qiao
Nov 11, 2008·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sanjay KakarLinda D Ferrell
Apr 25, 2007·Advances in Anatomic Pathology·Michael Torbenson
May 16, 2012·The Journal of Clinical Investigation·Jian HongTiebang Kang
Aug 28, 2021·Microorganisms·Maria BousaliTimokratis Karamitros
May 13, 2021·Visceral Medicine·Markus CasperSusanne N Weber

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