PMID: 7515464Jun 1, 1994Paper

Cytogenetic adaptive response with multiple small X-ray doses in mouse germ cells and its biological influence on the offspring of adapted males

Mutation Research
L CaiX G Piao

Abstract

Cytogenetic adaptive response of mouse germ cells was studied by exposing male mice to a sequence of 4 conditioning doses of 0.05 Gy each (D1) administered at 10-day intervals and subsequently to a single challenging dose of 1.5 Gy (D2). In concurrent experiments, male mice after treatment with D1 doses alone were mated to unirradiated females and the F1 males were given the D2 dose. Chromosomal aberrations in both spermatocytes and bone-marrow cells and UV-induced UDS in splenocytes of these mice were studied. Adapted mice (i.e., D1 + D2 exposures) responded with a significantly lower frequency of chromosomal aberrations than the non-adapted (D2 exposure only) controls. The relative reduction in frequencies was, however, similar to that observed in earlier work with a single conditioning dose of 0.05 Gy. The frequencies of chromosomal aberrations in spermatocytes and bone-marrow cells as well as the levels of UV-induced UDS in splenocytes of the F1 males in the group D1 to fathers + D2 to F1 males were the same as those in F1 males which received only the D2 exposure.

References

Feb 1, 1992·Mutation Research·J D Shadley, G Q Dai
Jan 1, 1990·Mutation Research·S FanW Burkart
Mar 1, 1989·Mutation Research·K SankaranarayananA T Natarajan

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Citations

Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·D R BorehamR E J Mitchel
Jul 31, 2010·International Journal of Radiation Biology·Eşref DemirRicardo Marcos
May 16, 2008·Human & Experimental Toxicology·Guan-Jun Wang Lu Cai
Aug 4, 2007·Critical Reviews in Toxicology·Guangwei LiuLu Cai
Mar 6, 2019·Dose-response : a Publication of International Hormesis Society·Kaihua JiQiang Liu

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