PMID: 7284987Aug 1, 1981

Cytogenetic analysis and flow cytometric DNA measurement of a human tumor with pronounced hypodiploidy

Cancer Genetics and Cytogenetics
S E PetersenU Friedrich


A case of malignant choroid plexus papilloma of the brain with severe hypodiploidy is presented. The hypodiploidy was estimated by means of flow cytometric measurements of the nuclear DNA content in two investigations with an interval of 21 months. The latter investigation was supplemented with chromosome analyses including quinacrine bonding. A modal chromosome number of 34 to 35 was found with a consistent loss of one chromosome Nos. 2, 3, 4, 5, 10, 13, 14, 15, 17, and 18, and no major structural changes. The corresponding calculated DNA content per nucleus correlated very well with the measured content, which was found to be 75% of the male diploid amount. The paper briefly discusses cell survival in extreme hypodiploidy and provides a comparison with cases from the literature in which banding analysis gives comparable information.


Jun 1, 1983·Cancer Genetics and Cytogenetics·B Pedersen, A M Boesen
Oct 1, 1985·Cancer Genetics and Cytogenetics·S H BignerD D Bigner
Apr 1, 1991·Cancer Genetics and Cytogenetics·C SreekantaiahA A Sandberg
Mar 1, 1995·Cancer Genetics and Cytogenetics·F MertensM Donnér
Mar 1, 1996·Cancer Genetics and Cytogenetics·Y S LiR F Armstrong
Sep 1, 1996·Cancer Genetics and Cytogenetics·B Roland, A Pinto
Jul 1, 1997·Cancer Genetics and Cytogenetics·S M Dobin, L R Donner
Aug 1, 1997·Cancer Genetics and Cytogenetics·M B BhattacharjeeL D Cooley
Apr 8, 1998·Cancer Genetics and Cytogenetics·D FlagielloB Dutrillaux
Jan 10, 2006·Neurosurgical Focus·Jane BayaniJeremy A Squire
Aug 1, 1990·Gynecologic Oncology·C SreekantaiahA A Sandberg
Aug 1, 1993·Genes, Chromosomes & Cancer·V DrouinB Debesse
Aug 1, 1994·Genes, Chromosomes & Cancer·H H PunnettP M Kanev
Feb 4, 2021·Methods and Protocols·Evrysthenis VartholomatosGeorgios S Markopoulos

Related Concepts

Brain Tumor, Recurrent
Partial Monosomy
Diploid Cell
DNA, Neoplasm
Papillary Ependymoma
Flow Cytometry
Karyotype Determination Procedure

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