PMID: 7523881Oct 1, 1994Paper

Cytogenetic analysis of lymphocytes from fiberglass-reinforced plastics workers occupationally exposed to styrene

Mutation Research
P Van HummelenM Kirsch-Volders

Abstract

In this study a group of 52 workers employed in a plant manufacturing fiberglass-reinforced plastic (FRP) pipes and cisterns, and therefore daily exposed to styrene, were monitored. As a control group 24 non-exposed workers from another factory producing and repairing pallets volunteered to participate. The airborne styrene during the monitoring ranged from 2.2 to 110.1 mg/m3. As a metabolic marker for styrene exposure mandelic acid was measured in the urine and ranged from 11 to 649 mg/g creatinine. From 43 exposed and 15 control workers sister-chromatid exchanges (SCE) and high frequency cell (HFC) data and from 49 exposed and 23 control workers micronucleus (MN) data from peripheral lymphocytes are reported. Although the two groups of workers could clearly be distinguished on the basis of the airborne styrene concentrations and urinary mandelic acid concentrations no differences in any of the cytogenetic markers were found. Correlations between the cytogenetic data and the level of airborne styrene concentrations or urinary mandelic acid levels could also not be demonstrated. Otherwise, smoking increased the SCE frequency. Grouping the workers according to smoking habits showed a statistically significant difference in SCE. ...Continue Reading

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Citations

Oct 24, 2002·Teratogenesis, Carcinogenesis, and Mutagenesis·Mehmet TopaktaşAhmet Kayraldiz
May 10, 2005·Mutation Research·Leigh M Henderson, Günter Speit
Apr 5, 2005·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·E R NestmannF Ratpan
Jan 21, 2006·Pharmacogenetics and Genomics·Lucia MiglioreAri Hirvonen
Jul 14, 2012·Journal of Toxicology and Environmental Health. Part a·Carla CostaJoão Paulo Teixeira
Dec 6, 2006·Drug Metabolism Reviews·Pavel VodickaFranz Oesch
Oct 7, 2004·Environmental and Molecular Mutagenesis·Lode GodderisDominique Lison
Jul 10, 2019·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·M I BantonS S Sarang

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