Cytogenetic analysis of unfertilized oocytes retrieved after treatment with the LHRH analogue, buserelin

Human Reproduction
J D A Delhanty, R J Penketh

Abstract

Chromosome analysis is reported on 155 oocytes from an in-vitro fertilization (IVF) programme in which the LHRH analogue, buserelin, was used in the superovulation regime. Seventy-one oocytes had the normal number of metaphase II chromosomes. Hyperhaploidy was apparent in four cases only; doubling this figure to include the reciprocally formed hypohaploid oocytes gave an aneuploidy rate due to non-disjunction of 10%. This is close to the figure for naturally occurring aneuploidy which may be calculated from data on recognized conceptions at a comparable maternal age. Taken together with the suggestion of a maternal age effect in our series these data suggest that follicular stimulation regimes which precede IVF do not necessarily add to the naturally high aneuploidy rate of the human species. Thirteen oocytes had failed to form the first polar body and the presence of diploid mitotic or sperm chromosomes provided evidence of fertilization and arrested development in 15. These figures for chromosomal anomalies following buserelin treatment are not significantly different from those obtained from comparable surveys following clomiphene citrate stimulation, providing no evidence that the improved pregnancy rate with buserelin is d...Continue Reading

Citations

Jun 4, 2002·Human Reproduction·R Dee SchrammBarry D Bavister
Aug 15, 2012·Journal of Assisted Reproduction and Genetics·I HammoudJ Selva
Jan 1, 1996·Environmental and Molecular Mutagenesis·U Eichenlaub-Ritter
Sep 30, 2005·Cytogenetic and Genome Research·F PellestorS Hamamah
Dec 1, 2004·Human Reproduction Update·F PellestorS Hamamah
Jan 1, 1995·Environmental and Molecular Mutagenesis·M A Abruzzo, T J Hassold
Oct 10, 2001·Human Fertility : Journal of the British Fertility Society·D Nugent, A H Balen
Jan 1, 1999·Maturitas·U Eichenlaub-Ritter
Feb 13, 2007·Environmental Research·F PacchierottiJ B Mailhes

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