Cytogenetic and clinicobiological features of acute leukemia with stem cell phenotype: study of nine cases

Cancer Genetics and Cytogenetics
A CuneoH Van den Berghe

Abstract

Morphologic, immunologic, cytogenetic, and clinical features were studied in 9 cases of acute undifferentiated leukemia (AUL). These patients were unclassifiable by FAB criteria, they were CD34+ and did not express myeloid- or lymphoid-associated antigens (CD13, CD33, CD14, CD15, CD61, CD19, CD10, CD22, CD7, CD2, CD5, CD3). Clonal abnormalities were seen in 8 of 9 cases. Del(5q) as the sole anomaly was observed in 3 cases; +13 was the primary change in 3 cases, and isolated trisomy 12 was found in 1 patient. A complex karyotype with trisomy 12q, in association with del 17p and trisomy 21q was detected in 1 case. One patient with 5q- relapsed with refractory anemia with excess of blasts; the presence of dysgranulopoiesis and a few blasts with possible monocytoid morphology in the remaining 2 patients point to a "myeloid nature" of these leukemias. Analysis of cytologic features in our 3 patients with +13, in combination with previously reported cases, suggests the occurrence of immature stem cell involvement with limited differentiation potential, possibly more along the myeloid than the lymphoid lineage. The significance of trisomy 12q in this subset of leukemia remains elusive; some clues of minimal differentiation towards the...Continue Reading

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Citations

Feb 16, 2013·Annals of Hematology·Sandra HeeschClaudia D Baldus
Nov 24, 1999·Cancer Genetics and Cytogenetics·K F WongY L Kwong
Aug 12, 2000·Cancer Genetics and Cytogenetics·Y ItoK Ohyashiki
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May 4, 2004·Cancer Genetics and Cytogenetics·Jeanna Welborn
Jun 2, 2006·Cytometry. Part B, Clinical Cytometry·Misbah QadirMaria R Baer
Mar 4, 2020·American Journal of Hematology·Sanjay S Patel, Olga K Weinberg
Jan 8, 2020·Journal of the National Comprehensive Cancer Network : JNCCN·Sandipkumar H PatelAlison Walker
Apr 20, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Olga K WeinbergDaniel A Arber
Mar 8, 2021·Pathology·Tracy I George, Ashish Bajel

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