PMID: 3971333Mar 1, 1985Paper

Cytogenetic and cytokinetic analysis of lymphocytes from patients with hereditary adenomatosis of the colon and rectum

Cancer Genetics and Cytogenetics
T KasukawaA Endo

Abstract

The frequencies of chromosome aberrations, sister chromatid exchanges (SCEs), and cell cycle kinetics were examined in cultured lymphocytes from five patients with hereditary adenomatosis of the colon and rectum (ACR) [three patients with Gardner's syndrome (GS) and two patients with familial polyposis coli (FPC)]. The frequency of numerical chromosome aberrations was no different in metaphase cells at the first and second replication cycles (M1 and M2) in the ACR patients and control subjects. The percentage of structural chromosome aberrations in both M1 and M2 cells was somewhat higher in the ACR patients as compared with the controls. Neither spontaneous nor mitomycin C-induced SCE frequencies in the patients with ACR were different from the controls, except for one patient with GS, who showed a remarkably high spontaneous SCE frequency. This patient is the mother of a son who had hepatoblastoma. The cell replication index (RI) was lower in the GS patients than in the controls. However, the RI in the FPC patients did not differ from that of the controls.

References

Feb 1, 1976·Journal of Medical Genetics·B S Danes
Jun 21, 1980·Lancet·J D DelhantyB Morson
Feb 20, 1982·Lancet·J E KingstonJ R Mann
Sep 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R ParshadG M Jones
Oct 1, 1982·Journal of the Medical Association of Thailand = Chotmaihet Thangphaet·C MeensookP Hetrakul
Jan 1, 1980·International Archives of Occupational and Environmental Health·T WatanabeM Ikeda
Apr 1, 1981·Scandinavian Journal of Gastroenterology·B S Danes, T Alm
Feb 12, 2008·Cirugía española·Teresa Ramón Y Cajal Asensio

Citations

Jul 1, 1989·Mutation Research·S HeimF Mertens
Jul 1, 1987·Cancer Genetics and Cytogenetics·R LukeisR H Whitehead
Nov 1, 1988·Cancer Genetics and Cytogenetics·P VernoleB Nicoletti
Apr 1, 1989·Cancer Genetics and Cytogenetics·M MulerisB Dutrillaux
Oct 1, 1990·Cancer Genetics and Cytogenetics·L BarriosJ Egozcue
Oct 1, 1987·American Journal of Medical Genetics·A Endo, T Kasukawa
Jan 1, 1987·Seminars in Surgical Oncology·A A Sandberg
Jun 1, 1987·American Journal of Medical Genetics·B TedeschiB Nicoletti

Related Concepts

Cell Cycle
Autosome Abnormalities
Malignant Tumor of Colon
Gardner Syndrome
Intestinal Polyps
Lymphoid Cells
Sister Chromatid Exchange

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