Cytogenetic and flow cytometric analysis of a clear cell chondrosarcoma

Cancer Genetics and Cytogenetics
C SreekantaiahA A Sandberg


Cytogenetic analysis of a rare tumor, a clear cell chondrosarcoma of the spine, showed unusual karyotypic findings. The tumor had a predominant clone with a near-haploid chromosome complement of 30 chromosomes with loss of one homologue of each chromosome pair except chromosomes 5, 7, 12, and 19-22. A second clone with 58-60 chromosomes appeared to have originated by a doubling of the near-haploid clone. No structural changes were present. Comparison with other solid tumors and leukemias with near-haploid chromosome complements showed an interesting difference in the chromosomes which were preferentially disomic or monosomic in the two groups. Quantitative DNA analysis also showed aneuploid clones of cells corresponding to the near-haploid and hyperdiploid chromosome counts obtained cytogenetically.


Jan 1, 1990·Genes, Chromosomes & Cancer·M Schwab, L C Amler
Jan 15, 1990·Cancer·N MandahlF Mitelman
Jun 1, 1990·Cancer Genetics and Cytogenetics·A GenescàJ Egozcue
Aug 1, 1990·Gynecologic Oncology·C SreekantaiahA A Sandberg
Mar 1, 1989·Cancer Genetics and Cytogenetics·Julia A BridgeJames R Neff
Jun 1, 1989·Cancer Genetics and Cytogenetics·C SreekantaiahA A Sandberg
Aug 1, 1989·Cancer Genetics and Cytogenetics·J A FletcherC C Morton
Aug 1, 1988·Cancer Genetics and Cytogenetics·N B Atkin, M C Baker
Jan 1, 1988·Cancer Genetics and Cytogenetics·C Turc-CarelA A Sandberg
Jan 15, 1986·Cancer Genetics and Cytogenetics·U KristofferssonF Mitelman
Oct 1, 1985·Cancer Genetics and Cytogenetics·S H BignerD D Bigner
Jan 15, 1985·Cancer Genetics and Cytogenetics·S H HinrichsA E Freeman
Oct 30, 1971·Lancet·M Seabright
Jun 1, 1983·Cancer Genetics and Cytogenetics·B Pedersen, A M Boesen
Jan 1, 1982·Medical and Pediatric Oncology·G A HoeltgeM L Slovak
Jun 1, 1981·Cancer Genetics and Cytogenetics·J M Trent, S E Salmon
Aug 1, 1981·Cancer Genetics and Cytogenetics·S E PetersenU Friedrich
Jan 1, 1981·Human Genetics·N B Atkin, M C Baker


Jan 1, 1993·Journal of Cancer Research and Clinical Oncology·C OrndalF Mitelman
Jun 1, 1992·Cancer Genetics and Cytogenetics·C OrndalF Mitelman
Dec 1, 1994·Cancer Genetics and Cytogenetics·L R Donner
Oct 1, 1994·Cancer Genetics and Cytogenetics·P P LongC A Griffin
Sep 1, 1994·Cancer Genetics and Cytogenetics·T DijkhuizenB de Jong
Apr 8, 1998·Cancer Genetics and Cytogenetics·D FlagielloB Dutrillaux
Sep 2, 1998·Cancer Genetics and Cytogenetics·Y Y OzisikA A Sandberg
Feb 12, 1999·Cancer Genetics and Cytogenetics·R NogueraA Llombart-Bosch
Oct 30, 2013·Diagnostic Cytopathology·Xiaoyin Sara JiangLeslie G Dodd
Nov 14, 2000·The American Journal of Pathology·J V BovéeP C Hogendoorn
Sep 15, 2005·Cancer Genetics and Cytogenetics·Jun NishioJulia A Bridge
Oct 15, 1994·Cancer·Y Y OzisikA A Sandberg
May 3, 2005·International Journal of Surgical Pathology·Anthony ChangBrian P Rubin
Jun 10, 2004·Current Opinion in Oncology·Avery A Sandberg
Aug 10, 2000·The American Journal of Surgical Pathology·R K KalilF H Sim

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