Cytogenetic and fluorescence in situ hybridization analysis of a basal cell adenocarcinoma of the mandible

Cancer Genetics and Cytogenetics
Esther ManorL Bodner

Abstract

Basal cell adenocarcinoma (BCAC) of the salivary glands is rare. Distant metastasis to the mandible from a salivary gland tumor is also considered rare. The cytogenetic finding of a case of metastatic BCAC of the mandible is described. We are unaware of earlier reports regarding cytogenetic findings of BCAC either at the primary site or at a distant metastasis site. An 80-year-old female with primary BCAC of the parotid salivary gland underwent parotidectomy and chemotherapy. One year later, a metastatic lesion in the mandible was found. Tissue specimens from the mandibular lesion were tested by the following pathologic methods: hematoxylin-eosin and immunohistochemistry for CK8/18, CK/903, vimentin, and smooth muscle actin. The characteristic histologic architecture of BCAC found in the mandible was similar to that of the earlier findings of the tumor in the parotid gland. A fresh sample from the mandibular lesion was examined by cytogenetics and fluorescence in situ hybridization (FISH), using centromeric probes for chromosomes 4, 8, 10, 18, and 22. A paraffin-embedded sample of the primary tumor was also examined by FISH. Cytogenetic and FISH analyses of the mandibular metastatic lesion revealed a clone with a pericentric in...Continue Reading

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Citations

Sep 15, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Jinglan LiuJean-Pierre de Chadarévian
Jan 29, 2010·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Esther ManorLipa Bodner
Dec 3, 2011·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Esther ManorLipa Bodner
Jun 15, 2012·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Esther ManorLipa Bodner
Jan 10, 2012·The British Journal of Oral & Maxillofacial Surgery·Esther ManorLipa Bodner
Oct 15, 2011·The British Journal of Oral & Maxillofacial Surgery·Esther ManorLipa Bodner
Aug 13, 2011·The British Journal of Oral & Maxillofacial Surgery·Esther ManorLipa Bodner
Dec 19, 2006·Cancer Genetics and Cytogenetics·Nina ScholzIrmgard Verdorfer
Jun 4, 2016·The American Journal of Surgical Pathology·Vickie Y JoJeffrey F Krane
Oct 27, 2015·Annals of Saudi Medicine·Si ChenXinming Chen

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