Abstract
Chronic myeloid leukemia (CML) is genetically characterized by the presence of the reciprocal translocation t(9;22)(q34;q11), resulting in a BCR/ABL gene fusion on the derivative chromosome 22 called the Philadelphia (Ph) chromosome. In 2-10% of the cases, this chimeric gene is generated by variant rearrangements, involving 9q34, 22q11, and one or several other genomic regions. All chromosomes have been described as participating in these variants, but there is a marked breakpoint clustering to chromosome bands 1p36, 3p21, 5q13, 6p21, 9q22, 11q13, 12p13, 17p13, 17q21, 17q25, 19q13, 21q22, 22q12, and 22q13. Despite their genetically complex nature, available data indicate that variant rearrangements do not confer any specific phenotypic or prognostic impact as compared to CML with a standard Ph chromosome. In most instances, the t(9;22), or a variant thereof, is the sole chromosomal anomaly during the chronic phase (CP) of the disease, whereas additional genetic changes are demonstrable in 60-80% of cases in blast crisis (BC). The secondary chromosomal aberrations are clearly nonrandom, with the most common chromosomal abnormalities being +8 (34% of cases with additional changes), +Ph (30%), i(17q) (20%), +19 (13%), -Y (8% of ma...Continue Reading
Citations
May 12, 2005·Cancer Immunology, Immunotherapy : CII·Yi ZengEmmanuel Katsanis
Oct 29, 2011·Cancer Immunology, Immunotherapy : CII·Michal Smahel
Feb 5, 2005·Annals of Hematology·Ulrike BacherClaudia Schoch
Jun 17, 2008·Annals of Hematology·Francesco AlbanoGiorgina Specchia
Mar 12, 2009·Annals of Hematology·Yenan LiJianxiang Wang
Mar 9, 2011·Annals of Hematology·Jungwon HuhDong Hwan Dennis Kim
Feb 22, 2012·Annals of Hematology·Qitian MuJie Jin
May 1, 2007·Current Hematologic Malignancy Reports·Tomasz Skorski
Feb 14, 2012·Current Hematologic Malignancy Reports·Tomasz Skorski
Mar 20, 2012·Current Hematologic Malignancy Reports·N MuvarakF V Rassool
Apr 5, 2011·Medical Oncology·Ayda BennourHalima Sennana
Jan 8, 2013·Medical Oncology·Sureyya BozkurtEmin Kansu
Aug 23, 2012·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M Dolores DelgadoJavier León
Mar 27, 2009·International Journal of Hematology·Marija Denčić-FeketeMirjana Gotić
Jul 1, 2009·International Journal of Hematology·Masayoshi MasukoYoshifusa Aizawa
Dec 10, 2009·International Journal of Hematology·Hiromichi MatsushitaHayato Miyachi
Feb 1, 2011·International Journal of Hematology·Masaya OkadaHiroyasu Ogawa
Mar 10, 2011·International Journal of Hematology·Veera S NadarajanZubaidah Zakaria
Mar 26, 2004·Cancer Genetics and Cytogenetics·Antonella ZagariaGiorgina Specchia
Feb 22, 2005·Cancer Genetics and Cytogenetics·Juan Pablo Meza EspinozaJuan Ramón González García
Jan 18, 2003·Leukemia Research·Xinwei ZhangJianxiang Wang
Dec 31, 2003·Cancer Genetics and Cytogenetics·Lisa Lee-JonesTerry Hoy
Jan 22, 2004·Cancer Genetics and Cytogenetics·Juan Pablo Meza EspinozaJuan Ramón González García
Sep 16, 2003·Blood Cells, Molecules & Diseases·Silvia BuonamiciGiuseppina Nucifora
Nov 21, 2008·Leukemia·J DierovM Carroll
Apr 11, 2008·Leukemia·M KoptyraT Skorski
Jul 31, 2009·Leukemia·J M GoldmanA M Vannucchi
Oct 30, 2009·Leukemia·C HaferlachT Haferlach
Apr 23, 2010·Leukemia·J BoultwoodJ S Wainscoat
Apr 4, 2006·Nature Medicine·Marion G OttManuel Grez
Mar 16, 2007·Nature Reviews. Cancer·Felix MitelmanFredrik Mertens
May 25, 2007·Nature Reviews. Cancer·Junia V Melo, David J Barnes
Jan 11, 2007·Bone Marrow Transplantation·K KarrmanB Johansson
Apr 29, 2005·Leukemia·M GiehlW Seifarth
Apr 29, 2005·Leukemia·A Krämer
Oct 7, 2006·Leukemia·S F YipL C Chan
Jun 29, 2007·Leukemia·M GiehlW Seifarth
Dec 7, 2007·Oncogene·F PerssonG Stenman
Jun 5, 2003·Seminars in Hematology·Michael W N Deininger
Nov 5, 2013·The New England Journal of Medicine·J E CortesUNKNOWN PACE Investigators
Oct 10, 2003·The New England Journal of Medicine·John M Goldman, Junia V Melo
Oct 27, 2010·Carcinogenesis·Daniela SallesEliana Abdelhay
Jun 30, 2011·Anti-cancer Drugs·Panagiotis T DiamantopoulosNora Viniou
Apr 2, 2005·Acta Haematologica·Li-Gen LiuAkiro Kimura
Nov 15, 2007·Cytogenetic and Genome Research·C J YeH H Q Heng
Jul 2, 2010·The Journal of Clinical Investigation·Danilo PerrottiTomasz Skorski
Jul 23, 2011·Genes & Cancer·M Dolores Delgado, Javier León
Jul 23, 2011·Genes & Cancer·Francis WienerSabine Mai
Sep 18, 2004·Blood·Yi ZengEmmanuel Katsanis
Aug 20, 2005·Blood·Yang DuNeal G Copeland