Cytogenetic biodosimetry and dose-rate effect after radioiodine therapy for thyroid cancer

Radiation and Environmental Biophysics
I K KhvostunovShunichi Yamashita

Abstract

This study set out to investigate chromosomal damage in peripheral blood lymphocytes of thyroid cancer patients receiving (131)I for thyroid remnant ablation or treatment of metastatic disease. The observed chromosomal damage was further converted to the estimates of whole-body dose to project the adverse side effects. Chromosomal aberration analysis was performed in 24 patients treated for the first time or after multiple courses. Blood samples were collected before treatment and 3 or 4 days after administration of 2-4 GBq of (131)I. Both conventional cytogenetic and chromosome 2, 4 and 12 painting assays were used. To account for dose-rate effect, a dose-protraction factor was applied to calculate the whole-body dose. The mean dose was 0.62 Gy (95% CI: 0.44-0.77 Gy) in the subgroup of patients treated one time and 0.67 Gy (95% CI: 0.03-1.00 Gy) in re-treated patients. These dose estimates are about 1.7-fold higher than those disregarding the effect of exposure duration. In re-treated patients, the neglected dose-rate effect can result in underestimation of the cumulative whole-body dose by the factor ranging from 2.6 to 6.8. Elevated frequency of chromosomal aberrations observed in re-treated patients before radioiodine thera...Continue Reading

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Citations

Oct 17, 2017·Journal of Radiation Research·Gordon K LivingstonAdayabalam S Balajee
Nov 6, 2018·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Adayabalam S Balajee, M Prakash Hande
Jul 8, 2021·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Adayabalam S BalajeeCarol J Iddins

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