Cytogenetic changes in nonmalignant breast tissue

Genes, Chromosomes & Cancer
M SteinarsdóttirH M Ogmundsdóttir

Abstract

Cytogenetic changes are common in breast cancer and have also been described in fibroadenomas and fibrocystic disease, but not in histologically normal breast tissue. Cytogenetic analysis was performed on nonmalignant breast tissue from benign breast lumps (n = 8), reduction mammoplasties (n = 31), and grossly nontumorous tissue from cancerous breasts (n = 84), using standard techniques and G-banding. All samples were reviewed histologically. Clonal chromosomal changes were found in three of eight benign breast tumors (38%). Of the reduction mammoplasties, 17 samples contained nonproliferative changes, and three of these (18%) showed a clonal deletion of 3p. No pathology was identified in the other 14 samples, of which one (7%) contained two clonal changes, apparently balanced translocations. Of nontumorous tissues from cancerous breasts, 15 (18%) showed clonal chromosomal abnormalities. Five of these samples were histologically normal. Two clones were identical to those found in the corresponding cancer. In 18 additional samples, single cells were detected with the same change as that seen in clones or single cells in the cancer. Only 4 of these 20 samples contained detectable cancer cells. Clonal abnormalities found in two or...Continue Reading

References

Jul 1, 1992·Genes, Chromosomes & Cancer·N PandisF Mitelman
May 1, 1991·Genes, Chromosomes & Cancer·G CalabreseG Palka
Jun 1, 1990·Cancer Genetics and Cytogenetics·D GeleickU Regenass
Mar 1, 1985·Cancer Genetics and Cytogenetics·S R WolmanA J Hackett
Sep 27, 1995·International Journal of Cancer. Journal International Du Cancer·M R TeixeiraS Heim
Jan 3, 1995·International Journal of Cancer. Journal International Du Cancer·C U DietrichS Heim
Jan 1, 1993·Advances in Experimental Medicine and Biology·J C EmersonJ M Trent
Aug 1, 1993·Cancer Genetics and Cytogenetics·C RohenJ Bullerdiek
Jan 1, 1995·Advances in Cancer Research·B Dutrillaux
Apr 1, 1996·Cancer Genetics and Cytogenetics·C RohenJ Bullerdiek
Jan 27, 1997·International Journal of Cancer. Journal International Du Cancer·C PeterssonF Mitelman
Dec 31, 1997·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·S SigurdssonE Jonsson
Aug 26, 1998·Genes, Chromosomes & Cancer·M R TeixeiraS Heim
Dec 9, 1998·Cancer Genetics and Cytogenetics·C P LundinN Pandis
Jan 7, 1999·Breast Cancer Research and Treatment·C Lundin, F Mertens
Jan 12, 2000·The Journal of Pathology·S R LakhaniM J O'Hare
May 10, 2001·Current Opinion in Cell Biology·A R Venkitaraman
Jul 27, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·R R BurbanoC Casartelli
Aug 9, 2001·Neoplasia : an International Journal for Oncology Research·M R TeixeiraS Heim
Oct 13, 2001·Breast Cancer Research : BCR·I P Tomlinson
Dec 18, 2001·Genes, Chromosomes & Cancer·Manuel R TeixeiraSverre Heim
Dec 26, 2001·Cancer Genetics and Cytogenetics·L R CavalliI J Cavalli
Nov 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Martin A NowakChristoph Lengauer
Dec 4, 2002·Genes, Chromosomes & Cancer·Ioannis PanagopoulosBertil Johansson

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Citations

Jul 28, 2007·Cancer Genetics and Cytogenetics·Sigríthur K BodvarsdóttirJorunn E Eyfjörd
Dec 7, 2007·International Journal of Cancer. Journal International Du Cancer·Anusri TripathiCarol L Rosenberg
Sep 13, 2011·Genes, Chromosomes & Cancer·Margret SteinarsdottirHelga M Ogmundsdottir
Jan 3, 2006·Journal of Theoretical Biology·Heiko EnderlingJayant S Vaidya
Nov 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Pamela S LarsonCarol L Rosenberg
Oct 13, 2007·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jean-Pierre de ChadarévianMartin J Herman
Aug 26, 2016·Breast Cancer : Basic and Clinical Research·David N Danforth
Sep 10, 2011·Medicine and Science in Sports and Exercise·William R LunnNancy R Rodriguez
Sep 28, 2018·Clinical Orthopaedics and Related Research·Mohammad A ElalfyJohn H Healey
Apr 5, 2008·Physical Therapy·Mary Kent HastingsDavid R Sinacore
Jul 17, 2008·Nucleic Acids Research·Chung-Sheng LeeRobin Reed
Jan 24, 2013·Lab on a Chip·Hyoungseon ChoiTaek Dong Chung

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