PMID: 20658094Jul 27, 2010Paper

Cytogenetic characterization and evaluation of c-MYC gene amplification in PG100, a new Brazilian gastric cancer cell line

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
H F RibeiroM O Bahia

Abstract

Gastric cancer is the fourth most frequent type of cancer and the second cause of cancer mortality worldwide. The genetic alterations described so far for gastric carcinomas include amplifications and mutations of the c-ERBB2, KRAS, MET, TP53, and c-MYC genes. Chromosomal instability described for gastric cancer includes gains and losses of whole chromosomes or parts of them and these events might lead to oncogene overexpression, showing the need for a better understanding of the cytogenetic aspects of this neoplasia. Very few gastric carcinoma cell lines have been isolated. The establishment and characterization of the biological properties of gastric cancer cell lines is a powerful tool to gather information about the evolution of this malignancy, and also to test new therapeutic approaches. The present study characterized cytogenetically PG-100, the first commercially available gastric cancer cell line derived from a Brazilian patient who had a gastric adenocarcinoma, using GTG banding and fluorescent in situ hybridization to determine MYC amplification. Twenty metaphases were karyotyped; 19 (95%) of them presented chromosome 8 trisomy, where the MYC gene is located, and 17 (85%) presented a deletion in the 17p region, where...Continue Reading

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Citations

Jul 10, 2012·BMC Gastroenterology·Tanielly Cristina Raiol SilvaRommel Rodríguez Burbano
Aug 4, 2011·PloS One·Joana de Fátima Ferreira Borges da CostaRommel Rodriguez Burbano
May 30, 2013·PloS One·Carolina Rosal Teixeira de SouzaRommel Rodríguez Burbano
Apr 18, 2012·World Journal of Gastroenterology : WJG·Mariana Ferreira LealMarília de Arruda Cardoso Smith
Jun 19, 2012·Clinical and Experimental Medicine·Mariana Ferreira LealRommel Rodríguez Burbano
Sep 29, 2011·Journal of Applied Toxicology : JAT·Diego Di Felipe Ávila AlcântaraMarcelo de Oliveira Bahia
Nov 15, 2015·Clinical and Experimental Medicine·Fernanda WisnieskiMarília Cardoso Smith
Apr 30, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Mariana Ferreira LealMarilia Cardoso Smith
Mar 9, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Plínio Cerqueira Dos Santos CardosoRommel Mário Rodríguez Burbano
May 30, 2019·Future Medicinal Chemistry·Ana C AnauateMarília A C Smith
Nov 10, 2018·Canadian Journal of Gastroenterology & Hepatology·Jersey Heitor da S MauésRommel M Rodríguez Burbano
Mar 11, 2020·International Journal of Molecular Sciences·Ana Carolina AnauateMarília Arruda Cardoso Smith
Dec 7, 2016·World Journal of Gastroenterology : WJG·Danielle Queiroz CalcagnoMarília Cardoso Smith

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