Cytogenetic effects of ethanol on chronic alcohol users

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Osman Demirhan, Deniz Tastemir

Abstract

Alcoholism is a significant public health problem that is also associated with a complex genetic trait. Fragile sites (FS) are potentially informative endpoints for the study of clinical disorders. We aimed to find chromosomal damages in chronic alcohol users for the purpose of finding the correlation between alcohol and chromosomal anomalies. The potential roles/effects of ethanol on chromosome(s) were assessed in this study by investigating its cytotoxic effects in lymphocyte cultures from chronic alcoholics and controls. Alcoholics revealed a significantly higher frequency of FS and chromosomal aberrations (CA), and the FS clusters in specific chromosomal regions: 1q12, 1q21, 1q32, 2p13, 2q21, 2q31, 3p14, 3p25, 3q21, 4q21, 4q31, 5q31, 6p21, 7q22, 7q32, 9q13, 9q22, 10q22, 11q23, and 12q13. We also observed a significantly greater number of numerical and structural CA in alcoholics. The most frequent exchange types were deletions and polymorphic variations. CA could be due to the cumulative effect of both alcohol and smoking. The loci 1q12, 3p25, 4q31, 6p21, and 12q13 were not reported previously in alcoholics and may be hot spots for alcoholism. The overall FS frequencies were not statistically different between smoker and no...Continue Reading

Citations

Feb 19, 2011·Cell Biology and Toxicology·Elisa CebralMarta Dolores Mudry
Aug 15, 2012·Journal of Molecular Neuroscience : MN·Yue PanLong-Yang Wu
Jul 5, 2012·Journal of Thyroid Research·Laura W DillonYuh-Hwa Wang
Jul 6, 2010·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jelena KaticIlse Decordier
Jul 12, 2017·The Pharmacogenomics Journal·A SulovariD Li
Jun 8, 2018·Balkan Journal of Medical Genetics : BJMG·Šošić GmVarjačić M
Sep 17, 2014·Molecular Biology Reports·Alfredo SantovitoMassimiliano Delpero

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