Cytogenetic evaluation of medical students exposed to formaldehyde vapor in the gross anatomy dissection laboratory

Journal of American College Health : J of ACH
N Vasudeva, C Anand

Abstract

Formaldehyde (FA) is a potential carcinogen and mutagen. In addition to inducing genotoxic effects in subhuman laboratory tests, FA has been found to be mutagenic to cultured human cells. Evidence regarding the genotoxic potential of FA on exposed individuals at occupational levels is insufficient and conflicting. The authors of this study examined chromosomal aberrations in peripheral blood lymphocytes from a group of 30 medical students exposed to FA for 15 months in a gross anatomy dissection laboratory. The results were compared with similar analyses from 30 off-site, matched, unexposed controls. At average exposures of less than 1 ppm, 72-hour lymphocyte cultures of the study cohort did not reveal any difference in the incidences of chromosomal aberrations among the exposed and the control group by conventional Giemsa staining and G-banding.

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Citations

May 15, 2010·Archives of Toxicology·Gunnar Damgård Nielsen, Peder Wolkoff
Sep 27, 2001·Archives of Environmental Health·J D Thrasher, K H Kilburn
Feb 18, 2003·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·R G Liteplo, M E Meek
May 14, 2009·Journal of the National Cancer Institute·Laura E Beane FreemanMichael Hauptmann
Jun 2, 2006·Critical Reviews in Toxicology·Robert GoldenPeter G Shields
Apr 29, 2008·Regulatory Toxicology and Pharmacology : RTP·David PyattRobert Golden
Sep 29, 2004·Regulatory Toxicology and Pharmacology : RTP·Henry d'A Heck, Mercedes Casanova
Sep 28, 2005·Regulatory Toxicology and Pharmacology : RTP·Masato Naya, Junko Nakanishi
Sep 30, 2016·Critical Reviews in Toxicology·Richard J Albertini, Debra A Kaden
Oct 1, 2015·Workplace Health & Safety·Beuy Joob, Viroj Wiwanitkit
Oct 7, 2006·Journal of Proteome Research·Donggeun Sul

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