Cytogenetic features in myelodysplastic syndromes.

Annals of Hematology
Detlef Haase

Abstract

Myelodysplastic syndromes (MDS) comprise a group of bone marrow diseases characterized by profound heterogeneity in morphologic presentation, clinical course, and cytogenetic features. Roughly 50% of patients display clonal chromosome abnormalities. In several multicentric studies, the karyotype turned out to be one of the most important prognostic parameters and was incorporated into statistical models aiming for a better prediction of the individual prognosis like the International Prognostic Scoring System. However, due to the profound cytogenetic heterogeneity, the impact of many rare abnormalities as well as combinations of anomalies occurring in a substantial portion of patients with MDS is still unknown and can only be delineated on the basis of large international multicentric cooperations. Recently, the German-Austrian MDS Study Group presented cytogenetic findings in 2,072 patients with MDS, which serve as a basis for the characterization of the cytogenetic subgroups discussed in this article. The availability of new therapeutic options for low- and high-risk MDS targeted against distinct entities characterized by specific chromosome abnormalities, like 5q-deletions, monosomy 7, and complex abnormalities underlines th...Continue Reading

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Citations

Jul 12, 2011·Annals of Hematology·François MullierBernard Chatelain
Apr 1, 2011·Advances in Therapy·Maria Diez CampeloJesus Feliu Sanchez
May 27, 2009·Current Opinion in Hematology·Pearlie K Epling-Burnette, Alan F List
Nov 23, 2012·Journal of Medical Genetics·Lars Anders ForsbergJan Piotr Dumanski
Jun 20, 2013·Postgraduate Medical Journal·Lars Anders ForsbergJan Piotr Dumanski
Mar 6, 2009·Leukemia & Lymphoma·Peter Valent, Rotraud Wieser
Aug 23, 2011·Leukemia & Lymphoma·Nathalie Douet-GuilbertMarc De Braekeleer
Nov 19, 2010·Expert Review of Hematology·Judith NeukirchenUlrich Germing
Nov 8, 2011·Hematology/oncology Clinics of North America·Sa A Wang
Dec 1, 2010·Surgical Pathology Clinics·Sa A Wang
Sep 26, 2009·Clinical Lymphoma & Myeloma·Guillermo Garcia-Manero
Jan 15, 2009·Journal of Internal Medicine·M Jädersten, E Hellström-Lindberg
May 20, 2011·American Journal of Hematology·Guillermo Garcia-Manero
May 9, 2012·American Journal of Hematology·Fareeda Taher Nazer HussainAyalew Tefferi

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Methods Mentioned

BETA
MDS
chromosomal aberrations
methylation

Software Mentioned

IPSS

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