Cytogenetic findings in phyllodes tumors of the breast: karyotypic complexity differentiates between malignant and benign tumors

Human Pathology
C U DietrichSverre Heim

Abstract

Clonal karyotypic abnormalities were detected in short-term cell cultures from six phyllodes tumors of the breast. Whereas all five benign tumors had simple chromosomal changes, the highly malignant one had a near-triploid stemline, indicating that karyotypic complexity is a marker of malignancy in phyllodes tumors. Interstitial deletions of the short arm of chromosome 3, del(3)(p12p14) and del(3)(p21p23),were the only aberrations in two benign tumors. Cytogenetic polyclonality was detected in three benign tumors: two had cytogenetically unrelated clones, whereas the third had three different, karyotypically related cell populations as evidence of clonal evolution. The finding of clonal chromosome abnormalities in both the epithelial and connective tissue components of the phyllodes tumors indicates that they are genuinely biphasic, that is, that both components are part of the neoplastic parenchyma.

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Citations

Jan 16, 2016·Histopathology·Benjamin Y TanPuay Hoon Tan
Sep 8, 2004·Cancer Genetics and Cytogenetics·Luciane R CavalliBassem R Haddad
Oct 12, 2004·Cancer Genetics and Cytogenetics·Miriam L BarbosaIglenir J Cavalli
Feb 14, 2015·Breast Cancer Research and Treatment·Jeffrey Chun Tatt LimPuay Hoon Tan
Feb 14, 2013·Journal of Clinical Pathology·Rooshdiya Z KarimCheok Soon Lee
Dec 18, 2001·Genes, Chromosomes & Cancer·Manuel R TeixeiraSverre Heim
Sep 5, 2002·The Journal of Pathology·Arno KuijperPaul J van Diest
Mar 6, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marick LaéJérôme Couturier
Mar 27, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·C G KleerH A Oberman
Jan 7, 1999·Breast Cancer Research and Treatment·C Lundin, F Mertens
Nov 7, 2012·Journal of Pediatric Hematology/oncology·Charles WaltherFredrik Mertens
Jul 15, 1999·International Journal of Cancer. Journal International Du Cancer·S BirdsallJ Shipley
Apr 24, 2020·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Benjamin Yongcheng TanPuay Hoon Tan

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