Cytogenetic findings in thirty lung carcinoma patients

Cancer Genetics and Cytogenetics
S Berker-KaraüzümA Demircan

Abstract

Primary tissue cultures of human lung tumors were prepared from 30 cases of which 16 were diagnosed as squamous cell carcinoma, six adenocarcinoma, four adenosquamous cell carcinoma, three large cell carcinoma, and one small cell lung carcinoma. Chromosomal abnormalities were observed in 26 cases by cytogenetic studies with a GTG banding technique. Specific chromosome bands frequently involved in structural abnormalities were seen on 1p11, 1q11, 2p10, 6p10, 7q11, 7q22, 7q32, 8q22, 9q22, 11q11, 21q10, and Xq24. We assumed that especially i(2)(p10), i(9)(p10), i(21)(q10), t(11;12), t(14;15), del(X)(q24), and loss of the Y chromosome may play a role in the development of lung cancer as secondary changes. In this way, our cytogenetic findings provide evidence that multiple genetic lesions are associated with the pathogenesis of lung cancer.

References

Dec 1, 1979·Cancer·M F van der Riet-FoxW A van Niekerk
Jul 1, 1992·Genes, Chromosomes & Cancer·N PandisF Mitelman
Mar 1, 1992·Cancer Genetics and Cytogenetics·A Flüry-HérardB Dutrillaux
May 1, 1991·Genes, Chromosomes & Cancer·J Whang-PengJ D Minna
Nov 11, 1991·International Journal of Cancer. Journal International Du Cancer·C U LudwigJ P Obrecht
Jan 2, 1991·International Journal of Cancer. Journal International Du Cancer·L Doneda, L Larizza
Nov 1, 1990·Genes, Chromosomes & Cancer·I MiuraJ R Testa
Jul 1, 1990·Genes, Chromosomes & Cancer·R LukeisS Hasthorpe
Oct 1, 1990·Baillière's Clinical Haematology·S Heim
Jul 1, 1990·Genes, Chromosomes & Cancer·B WullichW Schempp
Sep 1, 1990·Cancer Genetics and Cytogenetics·I MiuraJ R Testa
Oct 1, 1990·Cancer Genetics and Cytogenetics·E Viegas-PéquignotB Dutrillaux
Feb 1, 1989·Mayo Clinic Proceedings·P A De FuscoG W Dewald
Feb 1, 1989·Mayo Clinic Proceedings·J Whang-Peng
Feb 1, 1989·Cancer Genetics and Cytogenetics·J ArnemannC Fonatsch
Jun 1, 1989·Cancer Genetics and Cytogenetics·A Selypes, A László
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A WestonB F Trump
Mar 1, 1989·Cancer Genetics and Cytogenetics·M J BelloJ A Rey
Jun 1, 1989·Cancer Genetics and Cytogenetics·P T CagleF F Elder
Mar 15, 1985·Cancer Genetics and Cytogenetics·W H FalorS Wegryn
Jul 1, 1988·Cancer Genetics and Cytogenetics·Y S JinF Mitelman
Apr 1, 1987·Cancer Genetics and Cytogenetics·J A ReyJ Benítez
Feb 15, 1985·Cancer Genetics and Cytogenetics·J R TeyssierF Pigeon
Jun 1, 1982·Cancer Genetics and Cytogenetics·J Whang-PengJ D Minna
Jun 1, 1994·Leukemia & Lymphoma·S A Ridge, L M Wiedemann
Sep 30, 1993·International Journal of Cancer. Journal International Du Cancer·R CenterO M Garson
Jul 1, 1994·International Journal of Oncology·M JohanssonS Heim

❮ Previous
Next ❯

Citations

Apr 12, 2001·Cancer Genetics and Cytogenetics·L DanoD Laurent
Oct 9, 2002·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Masao ChujoYutaka Tagawa
Nov 6, 2004·Cancer Genetics and Cytogenetics·Jeanna WelbornPaula Walling
Sep 15, 2005·Cancer Genetics and Cytogenetics·Mira GrigorovaPaul A W Edwards
Jan 16, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Nihal InandiklioğluAtila Tanyeli
Jun 18, 2020·Frontiers in Oncology·Ning LiuHailong Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.