Abstract
Bladder cancer is a common malignancy in developing countries in which bladder infection with the parasite Schistosoma haematobium is prevalent. Several epidemiological, histopathological, and clinical characteristics of schistosoma-associated bladder cancer suggest that it is distinct from bladder cancer seen in other places in the world. The aim of this study was to extend establishing the cytogenetic profile of this type of malignancy in advanced and metastatic cases, and to demonstrate its relation to the end results of systemic therapy. Fluorescence in situ hybridization was applied to interphase nuclei to detect numerical chromosome changes in 41 patients with bladder cancer. Numerical chromosome aberrations were detected in 27 of 41 cases (66%). In 17 (41%) cases, a gain of chromosome 7 was observed, while losses in chromosomes 9 and 17 were detected in 20 (49%) and 18 (44%) cases, respectively. Loss of chromosome Y was detected in 7 of the 32 male patients included in this study (22%). There was a statistically significant association between stage of the disease and overall survival; Bajorin score and time to disease progression and overall survival; and between response to systemic therapy and time to disease progress...Continue Reading
References
Jan 1, 1992·Oncology·K SasakiS Hara
Jan 1, 1993·World Journal of Urology·C BillereyJ P Carbillet
Dec 15, 1995·Cytometry·S E ShackneyC A Smith
Jan 1, 1997·International Journal of Urology : Official Journal of the Japanese Urological Association·M TsutsumiH Akaza
Aug 1, 1997·The Journal of Urology·M A GhoneimA Ashamallah
Aug 28, 1998·The Journal of Urology·A PychaM Marberger
Oct 17, 1998·Journal of the National Cancer Institute·J G CairncrossD N Louis
Mar 7, 2000·The American Journal of Pathology·W El-RifaiS Knuutila
Aug 30, 2000·Carcinogenesis·M MuscheckF M Waldman
Jul 31, 2001·Molecular Pathology : MP·M A Knowles
Jan 22, 2002·Cancer Genetics and Cytogenetics·Magdy Sayed Aly, Hussein Mostafa Khaled
Dec 13, 2003·Urologic Oncology·Hussein M KhaledNadia Mokhtar
Jan 22, 2004·Journal of the National Cancer Institute·Bret TabackDave S B Hoon
Dec 22, 2004·Urologic Oncology·Hussein Mostafa KhaledNadia Mokhtar
Jul 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans von der MaaseMichael Arning
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Reimar AbrahamRaffaele Baffa
Jul 17, 2008·Cancer·David J GallagherDean F Bajorin
Jun 19, 2009·Cancer·Robert DreicerGeorge Wilding
Jan 27, 2010·Neoplasma·H GreslikovaP Kuglik
Citations
Feb 28, 2015·Izvestiia Akademii nauk. Seriia biologicheskaia·O E Mazur, A S Fomina
Jan 16, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Hussain Gadelkarim Ahmed
Nov 20, 2012·Journal of the Egyptian National Cancer Institute·Mohamed S Zaghloul
Feb 27, 2016·Pathology, Research and Practice·Rania MakboulMahmoud Rezk Abdelwahed Hussein
Oct 5, 2018·World Journal of Urology·Moritz MaasTilman Todenhöfer
Jul 3, 2021·Biology·Muhammad Nur Adam HattaHui-Min Neoh