Cytogenetic profile of locally advanced and metastatic Schistosoma-related bladder cancer and response to chemotherapy

Cancer Genetics
M S AlyTarek D Hussein

Abstract

Bladder cancer is a common malignancy in developing countries in which bladder infection with the parasite Schistosoma haematobium is prevalent. Several epidemiological, histopathological, and clinical characteristics of schistosoma-associated bladder cancer suggest that it is distinct from bladder cancer seen in other places in the world. The aim of this study was to extend establishing the cytogenetic profile of this type of malignancy in advanced and metastatic cases, and to demonstrate its relation to the end results of systemic therapy. Fluorescence in situ hybridization was applied to interphase nuclei to detect numerical chromosome changes in 41 patients with bladder cancer. Numerical chromosome aberrations were detected in 27 of 41 cases (66%). In 17 (41%) cases, a gain of chromosome 7 was observed, while losses in chromosomes 9 and 17 were detected in 20 (49%) and 18 (44%) cases, respectively. Loss of chromosome Y was detected in 7 of the 32 male patients included in this study (22%). There was a statistically significant association between stage of the disease and overall survival; Bajorin score and time to disease progression and overall survival; and between response to systemic therapy and time to disease progress...Continue Reading

References

Jan 1, 1997·International Journal of Urology : Official Journal of the Japanese Urological Association·M TsutsumiH Akaza
Oct 17, 1998·Journal of the National Cancer Institute·J G CairncrossD N Louis
Mar 7, 2000·The American Journal of Pathology·W El-RifaiS Knuutila
Jul 31, 2001·Molecular Pathology : MP·M A Knowles
Jan 22, 2002·Cancer Genetics and Cytogenetics·Magdy Sayed Aly, Hussein Mostafa Khaled
Dec 13, 2003·Urologic Oncology·Hussein M KhaledNadia Mokhtar
Dec 22, 2004·Urologic Oncology·Hussein Mostafa KhaledNadia Mokhtar
Jul 22, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hans von der MaaseMichael Arning
Nov 28, 2006·Frontiers in Bioscience : a Journal and Virtual Library·Reimar AbrahamRaffaele Baffa

❮ Previous
Next ❯

Citations

Jan 16, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Hussain Gadelkarim Ahmed
Nov 20, 2012·Journal of the Egyptian National Cancer Institute·Mohamed S Zaghloul
Feb 27, 2016·Pathology, Research and Practice·Rania MakboulMahmoud Rezk Abdelwahed Hussein
Oct 5, 2018·World Journal of Urology·Moritz MaasTilman Todenhöfer
Jul 3, 2021·Biology·Muhammad Nur Adam HattaHui-Min Neoh

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.