PMID: 2507914Oct 1, 1989Paper

Cytogenetic response to 1,2-dicarbonyls and hydrogen peroxide in Chinese hamster ovary AUXB1 cells and human peripheral lymphocytes

Mutation Research
J D TuckerA V Carrano

Abstract

Mutagenic 1,2-dicarbonyls have been reported to occur in coffee and other beverages and in various foods. We have measured the induction of sister-chromatid exchanges (SCEs) and endoreduplicated cells (ERCs) to determine the genotoxicity of various 1,2-dicarbonyl compounds in Chinese hamster ovary (CHO) AUXB1 cells and human peripheral lymphocytes. The 1,2-dicarbonyls glyoxal, methylglyoxal and kethoxal each induced highly significant increases in both SCEs and ERCs in AUXB1 cells. Glyoxal and kethoxal induced SCEs but not ERCs in human peripheral lymphocytes. In addition, hydrogen peroxide induced highly significant levels of SCEs and ERCs in AUXB1 cells. Bisulfite, which reacts with carbonyl groups to form addition products, significantly reduced the frequency of SCEs and the proportion of ERCs when glyoxal, methylglyoxal, kethoxal and diacetyl were administered to AUXB1 cells. In addition, bisulfite blocked the formation of ERCs, but not SCEs, induced by hydrogen peroxide. These in vitro results suggest that 1,2-dicarbonyls may play an important role in the genotoxicity of some foods and beverages.

References

Jan 1, 1977·Mutation Research·R Shapiro
Jan 1, 1988·Environmental and Molecular Mutagenesis·B S ShaneC B Henry
May 1, 1988·Mutation Research·R Menghini
Jun 3, 1988·Science·J A Imlay, S Linn
Aug 1, 1986·Environmental Health Perspectives·M NagaoT Sugimura
Jan 1, 1987·Mutation Research·E CajelliG Brambilla
Dec 1, 1985·Mutation Research·Y FujitaT Sugimura
Aug 1, 1985·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H U AeschbacherR Munoz-Box
Jul 1, 1981·Mutation Research·S A LattS Wolff
Dec 1, 1982·Mutation Research·Y SuwaT Sugimura
Jun 1, 1981·Cancer Genetics and Cytogenetics·S Sutou
Oct 1, 1984·Mutation Research·F NakasatoT Sugimura
Jan 1, 1982·Environmental Mutagenesis·G SpeitM Wolf
Jan 1, 1965·Cytogenetics·H G SCHWARZACHER, W SCHNEDL

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Citations

Sep 1, 1996·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Y Li
Jul 26, 2003·Biochimica Et Biophysica Acta·Ludmil BenovFatima Sequeira
Oct 4, 2005·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·I C MunroR Kroes
Jul 13, 2006·Journal of Esthetic and Restorative Dentistry : Official Publication of the American Academy of Esthetic Dentistry ... [et Al.]·Ian C MunroRobert Kroes
Jun 12, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Camilla SvendsenTrine Husøy

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