Cytogenetic results of choroidal nevus growth into melanoma in 55 consecutive cases

Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society
Carol L ShieldsArupa Ganguly

Abstract

To investigate the cytogenetic results of choroidal nevus with photographically-documented transformation into choroidal melanoma. Retrospective analysis of 55 consecutive patients who underwent fine needle aspiration biopsy (FNAB) for DNA isolation and whole genome array based assay for chromosomes 3, 6, and 8 analysis prior to plaque radiotherapy. Tumors with abnormalities in chromosomes 3 and 8 were considered high-risk for metastasis. At diagnosis of choroidal nevus the mean patient age was 57 years (median 57, range 10-83 years). All patients were Caucasian and 36 (65%) were female. At the time of nevus diagnosis, the mean tumor basal diameter was 7.4 mm (median 6.5, range 1.5-18.0 mm) and tumor thickness was 2.2 mm (median 2.2, range 0.5-3.9 mm). The mean interval between diagnosis of choroidal nevus and transformation into choroidal melanoma was 58 months (median 42, range 3-238 months). At the time of melanoma diagnosis, the mean tumor basal diameter was 9.7 mm (median 9.0, range 5.0-19.0) and tumor thickness was 3.5 mm (median 3.4, range 1.3-8.1). Cytogenetic analysis of FNAB-isolated melanoma revealed 25 patients (45%) with high-risk and 30 (55%) with low-risk cytogenetic findings. The rate of tumor growth into melano...Continue Reading

References

Mar 18, 2000·Archives of Ophthalmology·C L ShieldsC Carvalho
Feb 26, 2003·Investigative Ophthalmology & Visual Science·Andrea G M ScholesJohn K Field
Sep 13, 2005·Ophthalmology·Arun D SinghAllan Topham
Apr 28, 2006·Investigative Ophthalmology & Visual Science·J William Harbour
Aug 19, 2007·Ophthalmology·Carol L ShieldsJerry A Shields
Aug 28, 2007·Ophthalmology·Bertil DamatoPeter Howard
Apr 15, 2009·Archives of Ophthalmology·Bertil Damato, Sarah E Coupland
Aug 12, 2009·Archives of Ophthalmology·Carol L ShieldsJerry A Shields
Dec 9, 2009·Ophthalmology·Helen K LiJerry A Shields
Jul 4, 2013·Investigative Ophthalmology & Visual Science·Kathryn G EwensArupa Ganguly
Sep 10, 2013·Seminars in Ophthalmology·Xiang Q WerdichIvana K Kim
Mar 13, 2014·Current Opinion in Ophthalmology·Carol L ShieldsJerry A Shields
Jun 28, 2014·Investigative Ophthalmology & Visual Science·Kathryn G EwensArupa Ganguly
Apr 2, 2015·Indian Journal of Ophthalmology·Swathi KalikiJerry A Shields
May 16, 2015·Journal français d'ophtalmologie·M NielsenM J Jager
Jun 19, 2015·Melanoma Research·Jackelien G M Van BeekEmine Kiliç
Feb 1, 2017·Current Opinion in Ophthalmology·Jason L ChienCarol L Shields

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Citations

Sep 20, 2019·The British Journal of Ophthalmology·Antonio YaghyCarol L Shields
Dec 14, 2018·The British Journal of Ophthalmology·Lauren A DalvinJerry A Shields
May 19, 2021·Translational Vision Science & Technology·Carol L ShieldsMark S Blumenkranz

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Methods Mentioned

BETA
biopsy

Software Mentioned

Affymetrix
ChAS

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