PMID: 2246022Mar 1, 1990Paper

Cytogenetic studies in a population suspected to have chromosomal abnormalities

Indian Journal of Pediatrics
V C ShahS K Murthy


The present study describes the cytogenetic findings in cases suspected with chromosomal abnormalities, in cases of mental retardation, multiple congenital malformations, clinical features of Down's syndrome, Klinefelter's syndrome, Turner's syndrome, ambiguous sex, sterility, amenorrhea and history of repeated spontaneous abortions in couples. Cytogenetic studies were done in 144 of the total 205 cases. In all, 57 (39.58%) were shown to have chromosomal abnormality and of these, 34 cases (25.7%) were Down's syndrome. Sex chromosome abnormality was found in 19 cases (13.2%). The results confirm the significant contribution of chromosomal abnormalities in the genesis of mental retardation, and abnormal sexual development.


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Apr 14, 2010·Genetic Testing and Molecular Biomarkers·Seetha DayakarVimarsh Raina

Related Concepts

Autosome Abnormalities
Chromosome Banding
Karyotype Determination Procedure
Autosomal Chromosome Disorders

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