Cytogenetic survey of 53 Moroccan patients with acute myeloblastic leukemia

Cancer Genetics and Cytogenetics
N HdaA Benslimane

Abstract

We present a cytogenetic survey of chromosome aberrations for 53 Moroccan patients with acute myeloblastic leukemia (AML). Our 53 patients were 2 to 70 years old with 31 men and 22 women. The cytogenetic study was performed with the following three methods: first, relative proportion of normal (N) or abnormal (A) metaphases; second, presence of specific or random abnormalities; and third, karyotype complexity. Among 36 patients (67%) with a chromosomal abnormality, 18 (34%) showed a specific aberration. We have found t(9;22) in three patients (5%), chromosome 5 or 7 abnormality in six (11%), del(11)(q23) in three (6%), +21 in four (8%), and +8 in two (4%). Specific translocations associated with FAB type were found: t(8;21) with AML2 in 12 patients (23%) and t(9;11) with AML5 in one (2%). Rare abnormalities were also found: one patient with t(7;21) associated with AML2 and another patient with r(1) ring associated with AML1. We concluded that our study in a Moroccan population confirmed the relation between some specific abnormalities and the FAB classification. We have found a higher incidence for t(8;21) than usually described. Finally, we have identified chromosomal abnormalities t(7;21)(q22;p11) and r(1), rarely described b...Continue Reading

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Citations

Jun 18, 2003·Cancer Genetics and Cytogenetics·Judith DierlammDieter Kurt Hossfeld
Apr 6, 2002·Annales de génétique·Halima Sennana SendiAli Saad
Oct 3, 2006·Cancer Genetics and Cytogenetics·Tor OnstenGiorgio Paskulin
Jun 19, 2008·Cancer Genetics and Cytogenetics·Atsushi FujiedaNaoyuki Katayama
Jul 5, 2018·Journal of Oncology·Samra WaheedTahir S Shamsi

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