Abstract
We present a cytogenetic survey of chromosome aberrations for 53 Moroccan patients with acute myeloblastic leukemia (AML). Our 53 patients were 2 to 70 years old with 31 men and 22 women. The cytogenetic study was performed with the following three methods: first, relative proportion of normal (N) or abnormal (A) metaphases; second, presence of specific or random abnormalities; and third, karyotype complexity. Among 36 patients (67%) with a chromosomal abnormality, 18 (34%) showed a specific aberration. We have found t(9;22) in three patients (5%), chromosome 5 or 7 abnormality in six (11%), del(11)(q23) in three (6%), +21 in four (8%), and +8 in two (4%). Specific translocations associated with FAB type were found: t(8;21) with AML2 in 12 patients (23%) and t(9;11) with AML5 in one (2%). Rare abnormalities were also found: one patient with t(7;21) associated with AML2 and another patient with r(1) ring associated with AML1. We concluded that our study in a Moroccan population confirmed the relation between some specific abnormalities and the FAB classification. We have found a higher incidence for t(8;21) than usually described. Finally, we have identified chromosomal abnormalities t(7;21)(q22;p11) and r(1), rarely described b...Continue Reading
References
Apr 21, 1977·Nature·V Lindgren, J D Rowley
Nov 1, 1979·Pediatric Research·A HagemeijerK Hählen
Jan 1, 1979·Human Genetics·E L PrigoginaI S Peterson
Jan 1, 1976·Cancer·M Sakurai, A A Sandberg
Jul 1, 1992·Genes, Chromosomes & Cancer·F Mitelman, S Heim
Mar 1, 1992·Cancer Genetics and Cytogenetics·G PalkaG Torlontano
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·H MiyoshiM Ohki
Dec 11, 1991·Proceedings of the National Academy of Sciences of the United States of America·S Ziemin-van der PoelJ D Rowley
Jul 1, 1989·Cancer Genetics and Cytogenetics·S C RaimondiD L Williams
Jul 15, 1989·Cancer Genetics and Cytogenetics·D C ArthurG W Dewald
Jul 15, 1988·Cancer Genetics and Cytogenetics·M Minamihisamatsu, T Ishihara
Oct 1, 1985·Annals of Internal Medicine·J M BennettC Sultan
Jul 15, 1984·Cancer·T W Smith, R I Davidson
Feb 1, 1983·Cancer Genetics and Cytogenetics·L M Webber, O M Garson
Feb 1, 1984·Cancer Genetics and Cytogenetics·J J Yunis
Mar 1, 1984·Cancer Genetics and Cytogenetics·C D BloomfieldA de la Chapelle
Jan 1, 1980·Leukemia Research·R BergerG Flandrin
Jun 1, 1981·Cancer Genetics and Cytogenetics·F Pasquali, R Casalone
Nov 1, 1981·Cancer Genetics and Cytogenetics·F MitelmanB Dallapiccola
Jul 15, 1994·Cancer Genetics and Cytogenetics·M GallegoS C Raimondi
Mar 1, 1994·Blood·J M Goldman
Jan 20, 1998·Annals of Hematology·X ThomasE Archimbaud
Citations
Jun 18, 2003·Cancer Genetics and Cytogenetics·Judith DierlammDieter Kurt Hossfeld
May 29, 2009·Leukemia·Y ChengJ Jin
Jun 2, 2009·Cancer Genetics and Cytogenetics·C Cameron YinGary Lu
Dec 23, 2008·Cancer Genetics and Cytogenetics·Gary LuLynne V Abruzzo
May 3, 2012·Hematology·Abir GmidèneAli Saad
Apr 6, 2002·Annales de génétique·Halima Sennana SendiAli Saad
Oct 3, 2006·Cancer Genetics and Cytogenetics·Tor OnstenGiorgio Paskulin
Jun 19, 2008·Cancer Genetics and Cytogenetics·Atsushi FujiedaNaoyuki Katayama
Jul 5, 2018·Journal of Oncology·Samra WaheedTahir S Shamsi