PMID: 7537710Apr 1, 1995Paper

Cytogenetic toxicity and no-effect limit dose of pesticides

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
D KumarS P Sinha

Abstract

The no-effect limit dose (NELD) of three commonly used pesticides with respect to their cytogenetic toxicity was determined in a number of test systems using a sufficient number of lower doses to characterize the dose-effect relationship. For lindane, malathion and metacid, this dose was 3.2, 7.0 and 3.0 mg/litre, respectively, for mitosis inhibition and 9.0, 55 and 60 mg/litre, respectively, for chromosome clastogeny in onion root-tip cells. For chromosome clastogeny in mice bone marrow cells, the NELDs of the three pesticides were 1.6, 1.5 and 2.0 mg/kg body weight/day, respectively. These values for dominant lethals and X-chromosome-linked recessive lethals in Drosophila were 20 and 5 micrograms lindane/litre, 2 and 3.5 micrograms malathion/litre and 4 and 5.5 micrograms metacid/litre, respectively. Thus, the NELDs are not only pesticide specific but also organism specific, tissue specific and even damage specific. Furthermore, the NELD values determined are so small that the real human exposure to pesticides cannot be reduced below these levels without compromising the effectiveness of pesticides in use.

References

Sep 1, 1990·Bulletin of Environmental Contamination and Toxicology·T S DikshithU N Adholia
Jan 1, 1990·Bulletin of Environmental Contamination and Toxicology·H W HogmireJ L Brooks
Dec 1, 1985·Bulletin of Environmental Contamination and Toxicology·S S Atuma
Jan 1, 1993·Mutation Research·P K Khan, S P Sinha
Mar 1, 1993·Mutation Research·Q Hoda, S P Sinha
Jan 1, 1994·Teratogenesis, Carcinogenesis, and Mutagenesis·P K Khan, S P Sinha
Jun 10, 2010·Expert Opinion on Drug Metabolism & Toxicology·Russell T NavenNigel Greene

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Citations

Jun 4, 2014·Journal of Hazardous Materials·Claire BlondelMuriel Raveton
Mar 17, 2012·Ecotoxicology and Environmental Safety·V P KesariP K Khan
Sep 2, 2005·Mutagenesis·G J S JenkinsJ M Parry
Jun 17, 2021·Brazilian Journal of Biology = Revista Brasleira De Biologia·N C GhisiE C Oliveira

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