Cytogenetics of Hispanic and White children with acute lymphoblastic leukemia in California

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Melinda C AldrichPatricia A Buffler

Abstract

Epidemiologic studies of childhood leukemia have made limited use of tumor genetic characteristics, which may be related to disease etiology. We characterized the cytogenetics of 543 childhood leukemia patients (0-14 years of age) enrolled in the Northern California Childhood Leukemia Study, an approximately population-based study comprised primarily of Hispanics (42%) and non-Hispanic Whites (41%), and compared the cytogenetic profiles between these two ethnic groups. Subjects were classified by immunophenotype, conventional cytogenetic characteristics, and fluorescence in situ hybridization findings. The ploidy levels most frequently observed among acute lymphoblastic leukemia patients were high hyperdiploidy (51-67 chromosomes) and pseudodiploidy (34% and 27%, respectively). No ethnic differences in the frequency of 11q23/MLL rearrangements were observed between Hispanics and non-Hispanic Whites. Among B-lineage acute lymphoblastic leukemia patients, the percentage of TEL-AML1 translocations was significantly lower in Hispanics (13%) than in non-Hispanic Whites (24%; P = 0.01). This is the first time that this ethnic variation has been observed in a large number of patients in a defined geographic region, which is consistent...Continue Reading

References

Jan 1, 1996·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M SmithR Ungerleider
Mar 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J E RubnitzF G Behm
May 1, 1996·Genes, Chromosomes & Cancer·A V MoormanL M Secker-Walker
Sep 17, 1998·Japanese Journal of Cancer Research : Gann·M Eguchi-IshimaeN Kamada
Apr 13, 1999·Cancer Genetics and Cytogenetics·D H SpathasJ M Connor
Nov 7, 1999·Lancet·J L WiemelsM F Greaves
Dec 3, 1999·British Journal of Haematology·R García-SanzA Bortolucci
Feb 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B H PollockS B Murphy
Nov 25, 2000·British Journal of Haematology·I Q MagalhãesM F Greaves
Jul 3, 2002·Leukemia·O Hrusák, A Porwit-MacDonald
Oct 12, 2002·Medical and Pediatric Oncology·Dawn Elizabeth McNeilAlvin Mauer
Mar 7, 2003·Journal of Pediatric Hematology/oncology·Ugur OzbekGunduz Gedikoglu
Jun 28, 2003·Blood·Anthony V MoormanUNKNOWN United Kingdom Medical Research Council's Childhood Leukemia Working Party
Sep 3, 2003·Nature Reviews. Cancer·Mel F Greaves, Joe Wiemels
Mar 16, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Logan G SpectorJulie A Ross

❮ Previous
Next ❯

Citations

Oct 12, 2011·Cancer Causes & Control : CCC·Anand P ChokkalingamPatricia A Buffler
Jul 10, 2013·Cancer Causes & Control : CCC·Anand P ChokkalingamPatricia A Buffler
Oct 5, 2010·International Journal of Epidemiology·Karen BartleyPatricia Buffler
Feb 6, 2009·Journal of Pediatric Hematology/oncology·Carlos Santamaría-QuesadaMarcos González
Jan 24, 2009·Environmental Health Perspectives·Ghislaine ScéloPatricia A Buffler
Jul 7, 2009·Leukemia & Lymphoma·Alondra Daniel-CraviotoVilma Carolina Bekker-Mendez
Apr 25, 2007·Critical Reviews in Clinical Laboratory Sciences·Richard L Tower, Logan G Spector
Jul 28, 2015·Expert Review of Anticancer Therapy·Marc De BraekeleerNathalie Douet-Guilbert
Aug 7, 2010·Blood Cells, Molecules & Diseases·Joseph L WiemelsJohn K Wiencke
Jun 2, 2010·Cancer Genetics and Cytogenetics·Etienne De BraekeleerMarc De Braekeleer
Feb 18, 2011·Pediatric Blood & Cancer·Smita Bhatia
Jan 7, 2010·Cancer·Jennifer WorchSteven G DuBois
Aug 13, 2009·Pediatric Blood & Cancer·Francesco CeppiMaja Beck Popovic
Jun 11, 2015·International Journal of Cancer. Journal International Du Cancer·Helen D BaileyJoachim Schüz
Jun 19, 2015·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Ansar HakeemA R Lone
Jul 24, 2008·Journal of the National Cancer Institute. Monographs·Joseph Wiemels
Jun 21, 2018·International Journal of Cancer. Journal International Du Cancer·Adam J de SmithJoseph L Wiemels
May 19, 2019·Genes, Chromosomes & Cancer·Adam J de SmithJoseph L Wiemels
Jul 1, 2009·European Journal of Haematology·Kalliopi N Manola
Jan 7, 2020·Cancer Metastasis Reviews·Daniel HeinUte Fischer
Jun 6, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Kevin Y UrayamaJoseph L Wiemels
Jul 16, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Catherine MetayerPatricia A Buffler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.