Cytohistologic correlation of nuclear grade in breast carcinoma

Acta Cytologica
J A ZoppiA S Sundblad

Abstract

To compare the nuclear grade (NG) in cytologic material (CNG) obtained from breast fine needle aspiration biopsies (FNABs) with the NG observed in surgical biopsies (BNG) of the same tumors. The study group consisted of 135 breast carcinomas with both FNAB and biopsy. Most of them were invasive ductal carcinomas. Cytologic aspirates and tissue sections were graded simultaneously by the three authors using a multiheaded microscope. Fisher's modification of Black's nuclear grading scheme was used. There was agreement between CNG and BNG in 70.37% of tumors. The percentage coincidence was slightly greater for NG 3. Nuclear grade can be easily established on FNAB. The lack of correlation (29.63%) may have been due to tumor heterogeneity and observer subjectivity when assigning nuclear grade.

Citations

May 9, 2001·Breast Cancer : the Journal of the Japanese Breast Cancer Society·M SuzukiN Nakajima
Jul 10, 2014·ISRN Oncology·Dinisha EinstienSadaf Rahman
Oct 20, 2007·Cytopathology : Official Journal of the British Society for Clinical Cytology·T Sauer, M Karimzadeh
May 12, 2016·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·P Arul, Suresh Masilamani

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