Cytokeratin 7-positive/cytokeratin 20-negative cecal adenocarcinoma metastatic to the uterine cervix: a case report

World Journal of Surgical Oncology
Masafumi ToyoshimaKosuke Yoshinaga

Abstract

The vast majority of uterine cervical malignancies are primary carcinomas, and secondary neoplasms that metastasize to the uterine cervix from a distant organ are uncommon. Although relatively rare, metastases to the uterine cervix from a primary colon cancer have been reported. We report a rare case of metastatic carcinoma originating from a cecal adenocarcinoma with an unusual cytokeratin 7/cytokeratin 20 immunophenotype. A 74-year-old postmenopausal Japanese woman was referred to our hospital for the evaluation of a uterine tumor. She had a past medical history of cecal cancer and had undergone laparoscopically assisted right hemicolectomy at the age of 69 years. During follow-up, she was found to have elevated levels of the tumor markers carbohydrate antigen 19-9 (179.7 IU/mL) and carcinoembryonic antigen (26.9 μg/L). Positron emission tomography/computed tomography showed a focus of high 18F-fluorodeoxyglucose uptake in her uterus. Examination of a cervical biopsy found a poorly differentiated adenocarcinoma that was immunopositive for cytokeratin (CK)7 and caudal-related homeobox 2 (CDX2) expression and immunonegative for cytokeratin 20 expression. The patient underwent radical hysterectomy and bilateral salpingo-oophorec...Continue Reading

References

May 1, 1995·Gynecologic Oncology·G BorrasJ Iglesias
Mar 18, 2000·Japanese Journal of Clinical Oncology·K NakagamiY Morishita
Dec 25, 2007·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·W G McCluggageH A McBride
Apr 24, 2010·The American Journal of Surgical Pathology·W Glenn McCluggageKathryn Kennedy

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Citations

Jun 20, 2018·Clinical Nuclear Medicine·Hongxi WangRong Tian
Sep 11, 2020·The American Journal of Surgical Pathology·Gulisa TurashviliLars-Christian Horn

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Methods Mentioned

BETA
biopsy
hysterectomy
surgical resection
dissection

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