Cytokeratin expression in squamous cell carcinomas of the tongue and alveolar mucosa

European Journal of Cancer. Part B, Oral Oncology
M M VaidyaA N Bhisey

Abstract

Cytokeratins (CK), the intermediate filament markers for epithelial cells were analysed in 23 squamous cell carcinomas (SCC) of the tongue and 11 SCC of the alveolar mucosa (AM) by SDS-PAGE, immunoblotting and two dimensional gel electrophoresis. Normal human adult ventral tongue expresses CK nos 4, 5, 6, 13, 14, 16 (17) while the dorsal tongue expresses CK nos 1, 5, 6, 10, 14, 16 (17). CK 5 and CK 14 were not detected in a majority of samples and CK 18, a marker of simple epithelia, was aberrantly expressed in 18 samples. Normal human adult AM expresses CK nos 4, 5, 6, 13, 14, 16 (17). Among 11 SCC of AM, CK 4 and CK 5 were detected in only two samples each. CK 1 and CK 10 were aberrantly expressed in nine and one samples, respectively. The basic CKs such as CK 4, 5 and 14 were not expressed in SCC at both these sites while others like CK 1 and 18 were aberrantly expressed. Thus, non-expression of basic keratin, CK 5, of the oral lining epithelia and aberrant expression of simple epithelial keratins seem to be the major events in malignant transformation in the oral epithelia.

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Citations

Sep 1, 2007·Journal of Biosciences·Milind M Vaidya, Deepak Kanojia
Jan 30, 2004·Oral Oncology·Ojaswini S UpasaniAvinash N Bhisey
Jan 3, 2001·Clinics in Dermatology·T A Winning, G C Townsend
Jan 22, 2008·Oral Oncology·Sharada S SawantMilind M Vaidya
Jan 22, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·María L PaparellaAna R Raimondi
Dec 21, 2010·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Uta J E ThielJuergen Brieger
Feb 2, 2006·Oral Oncology·Deepak Kanojia, Milind M Vaidya
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Jun 9, 2012·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Kanwar Deep Singh NandaElizabeth Joshua
Dec 7, 2010·Oral Oncology·Sharada S SawantMilind M Vaidya
Oct 22, 2011·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Hye-Jung YoonSeong-Doo Hong
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