PMID: 7535804Jan 1, 1995Paper

Cytokeratin intermediate filament expression in benign and malignant breast disease

Journal of Clinical Pathology
M HeatleyP Toner

Abstract

To carry out a comprehensive study of cytokeratin expression in benign and malignant breast epithelium and breast myoepithelial cells; to examine changes in the cytokeratin profile in malignant and benign epithelium and in carcinomas of increasing histological grade. Frozen sections from fibroadenomas (19 cases), fibrocystic disease (19 cases), and infiltrating ductal (68 cases), lobular (seven cases), and mucinous carcinomas (three cases) were examined using a panel of monoclonal antibodies. The luminal epithelium in all fibroadenomas and all cases of fibrocystic disease, as well as tumour cells in most carcinomas, reacted with the specific antibodies to cytokeratins 7, 8, 18, and 19 and to antibodies which included these cytokeratins in their specificities (Cam 5.2, AE1, AE3, RCK102, and LP34). In a few ductal carcinomas none of the tumour cells reacted for cytokeratins 7, 8, or 18. Three ductal carcinomas expressed cytokeratin 14. Only occasional cases expressed cytokeratins 3, 4, 10, and 13. Antibodies which included cytokeratins 5 and 14 in their specificities detected myoepithelial cells less efficiently than antiactin antibodies. The cytokeratin profiles in the luminal epithelium in benign breast disease and in tumour ce...Continue Reading

References

Jun 1, 1991·Histopathology·A TsuburaS Morii
Apr 1, 1990·Differentiation; Research in Biological Diversity·C MørkO W Petersen
Jul 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R B NagleE D Jarasch
Oct 1, 1987·Breast Cancer Research and Treatment·S H DairkeeA Hackett
Jul 6, 1988·Journal of the National Cancer Institute·S H DairkeeA J Hackett
Aug 15, 1988·International Journal of Cancer. Journal International Du Cancer·V I GuelsteinG A Bannikov
Oct 1, 1988·Trends in Genetics : TIG·E Fuchs
Aug 1, 1988·Trends in Genetics : TIG·W Wahli

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Citations

May 3, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Rohit K JainSunil Badve
Mar 17, 2006·Applied Immunohistochemistry & Molecular Morphology : AIMM·Natália Guimaràes de Moraes SchenkaJose Vassallo
Apr 24, 2008·Pathology International·Masaki HasegawaMasahide Takahashi
Dec 20, 2011·Cancer Discovery·Chad V PecotAnil K Sood
Jan 16, 2007·Breast Cancer Research : BCR·Laura G FulfordSunil R Lakhani
Nov 4, 2010·Indian Journal of Pathology & Microbiology·Amarpreet BhallaNikita Kalra
Sep 20, 2005·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Gulisa TurashviliZdenek Kolár
Nov 27, 2014·Archives of Pathology & Laboratory Medicine·Haiyan Liu
Dec 17, 2015·Annals of Diagnostic Pathology·Hajime KurodaHisaki Fukushima
Mar 15, 2005·American Journal of Clinical Pathology·Ignacio CruzAlberto Orfao
Nov 30, 2004·Annales de pathologie·Jean-Christophe NoëlSergio Fernandez-Aguilar
Nov 26, 2009·The Breast Journal·Saima NazHui Xue
May 1, 2015·Revista Portuguesa De Pneumologia·Vitor SousaLina Carvalho
May 20, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Emad A RakhaIan O Ellis
Jul 21, 2004·Pathology International·Hee Jin ChangWoo Ho Kim
Aug 25, 2007·Advances in Anatomic Pathology·Oluwole Fadare, Fattaneh A Tavassoli
Jun 15, 2007·Journal of Health Communication·Michael Givel
Jul 4, 2020·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Jiyoung Kim, René Villadsen
Sep 28, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Chris JonesSunil R Lakhani
Jul 22, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sunil R LakhaniUNKNOWN Breast Cancer Linkage Consortium
Apr 9, 2002·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T Tot

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