Cytokeratin-positive fibroblastic reticular cell tumor with follicular dendritic cell features: a case report and review of the literature

The American Journal of Surgical Pathology
Naoe GotoMitsunori Yamakawa

Abstract

Fibroblastic reticular cell (FRC) neoplasms, which are one of the histiocyte tumor types, are very rare. Here we report a cytokeratin (CK)-positive FRC neoplasm having features of follicular dendritic cells in a 54-year-old woman with right axillary lymph node swelling. The resected lymph node showed multiple nodular aggregations simulating and replacing normal follicles. The tumor cells had a uniform, large and oval to polygonal shape, abundant cytoplasm, and various sizes of nuclei with central eosinophilic nucleoli and coarse nuclear chromatin. They were positive for CK AE1/AE3+CAM5.2, CK7, tenascin C, l-caldesomone, and CD21, weakly positive for S100, and negative for CD1a. Ultrastructurally, the tumor cells had long interdigitating microvillus-like cell processes and oval to elongated vesicular nuclei. In addition, the intercellular spaces contained accumulations of collagen, and some tumor cells had desmosomal-like junctions. These findings suggest that the present case is a CK-positive FRC tumor with follicular dendritic cell features.

References

Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·C DoglioniG Viale
Jan 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·V E GouldW W Franke
Oct 1, 1990·Immunological Reviews·J G TewA K Szakal
Oct 13, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·D JonesL J Medeiros
Jul 3, 2013·International Journal of Surgery Case Reports·Manabu FutamuraKazuhiro Yoshida

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BETA
biopsy
dissection
electron microscopy

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