PMID: 7545883Jun 1, 1995Paper

Cytokeratins as a marker for epicardial formation in the quail embryo

Anatomy and Embryology
M P Vrancken PeetersAdriana C Gittenberger-de Groot

Abstract

Several techniques have been used to visualize the migration pattern of the epicardial cells from the proepicardial organ over the myocardial surface. As the epicardial cells contain keratin tonofilament bundles, we have incubated 92 whole-mount quail hearts with an anti-keratin antibody. This immunohistochemical method showed that the complete epicardial covering of the embryonic heart is preceded by the formation of three epicardial rings. The epicardial rings are formed on the outer myocardial surface in the grooves that separate the cardiac segments from each other. We have also documented timing and patterning of isolated epicardial islands. They are not encountered at random over the myocardial surface, but only along the edge of the advancing epicardial front border and in two defined future epicardial ring areas on the ventral side of the outflow tract. The epicardial islands suggest that in the quail free-floating parts of epicardium can attach to the myocardium. Characteristics of the surface of the myocardium at the transitional zones between the cardiac segments, as well as the three-dimensional remodelling of the heart during cardiac morphogenesis seem to play a role in the pattern in which the epicardium eventuall...Continue Reading

Citations

Mar 24, 2007·Cellular and Molecular Life Sciences : CMLS·E M Winter, A C Gittenberger-de Groot
Nov 26, 2005·Angiogenesis·Robert J Tomanek
Apr 18, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·José M Pérez-PomaresAndy Wessels
Dec 31, 2003·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·A Wessels, J M Pérez-Pomares
Jun 2, 2012·Differentiation; Research in Biological Diversity·Adriana C Gittenberger-de GrootRobert E Poelmann
Jun 12, 2012·Differentiation; Research in Biological Diversity·Nynke M S van den AkkerDaniël G M Molin
Nov 4, 2015·Journal of Molecular and Cellular Cardiology·Tim P KelderMonique R M Jongbloed
Aug 29, 2009·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·José M IcardoValentín Sans-Coma
Aug 26, 2009·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Noortje A M BaxAdriana C Gittenberger-de Groot
Jan 16, 2016·Journal of Developmental Biology·Robert M KaoLisa Maves
Jun 7, 2006·Developmental Biology·Boudewijn P T KruithofMaurice J B van den Hoff
Dec 14, 2011·Circulation Research·José María Pérez-Pomares, José Luis de la Pompa
Jan 31, 2020·Circulation Research·Pearl QuijadaEric M Small
Jul 31, 2003·Cardiology in the Young·Adriana C Gittenberger-de Groot
Sep 24, 2015·Development·Catherine A RisebroPaul R Riley

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