PMID: 9630159Jun 18, 1998Paper

Cytokine and chemokine production in HSV-1 latently infected trigeminal ganglion cell cultures: effects of hyperthermic stress

Journal of Neuroimmunology
D J CarrI L Campbell

Abstract

The establishment of a primary trigeminal ganglion (TG) cell culture latently infected with herpes simplex virus type 1 (HSV-1) has been useful in studying stress-induced reactivation of the latent virus. However, the immune profile of this culture system prior to and after stress has never been established. In the present manuscript, cytokine and chemokine production were measured in primary cultures of TG cells obtained from uninfected and HSV-1 latently infected mice. Supernates from TG cell cultures contained detectable interleukin (IL)-6 but not IL-1beta, IL-2, IL-10, interferon (IFN)-gamma or tumor necrosis factor (TNF)-alpha as determined by ELISA. The basal level of IL-6 in uninfected TG cell cultures was 20.5 +/- 2.3 ng/ml, whereas latently infected TG cells produced significantly less IL-6 (12.1 +/- 1.9 ng/ml). Supernates from TG cell cultures also contained detectable levels of C-10, MCP-1 and eotaxin but little to no MIP-1alpha, MIP-1beta, or MIP-2. While there were no differences in the basal level of MCP-1 and eotaxin in TG cell cultures from HSV-1-infected and uninfected mice, C10 levels were significantly higher in TG cultures originating from infected mice compared to uninfected ones (5.86 +/- 0.61 ng/ml compar...Continue Reading

References

Feb 1, 1992·Immunological Investigations·H L EvanoffR M Strieter
Jul 1, 1991·The Journal of General Virology·R L HendricksJ C Glorioso
Dec 1, 1990·Journal of Neuroimmunology·E N BenvenisteG M Fuller
Aug 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·A P LiebermanM L Shin
Aug 1, 1989·The Journal of Experimental Medicine·F M HofmanJ E Merrill
Mar 1, 1989·Journal of the National Cancer Institute·J KuratsuT Yoshimura
Aug 1, 1986·The Journal of Experimental Medicine·D GiulianL B Lachman
Aug 5, 1983·Science·H BesedovskyC Honegger
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M C NussenzweigB Gutchinov
Jul 1, 1982·Pediatric Infectious Disease·P A OffitS A Plotkin
Nov 30, 1994·Experientia·T J Hall
Nov 5, 1997·Virology·W P HalfordD J Carr

❮ Previous
Next ❯

Citations

Oct 26, 1999·Trends in Neurosciences·V C Asensio, I L Campbell
Dec 19, 2002·Cytokine & Growth Factor Reviews·Amber D SteeleThomas J Rogers
Aug 30, 2008·Molecular Therapy : the Journal of the American Society of Gene Therapy·Masataka SuzukiYoshinaga Saeki
Nov 26, 2005·Uirusu·Kazuhiro Kondo
Jul 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Imre SzaboThomas J Rogers
Dec 10, 2009·Journal of Tissue Engineering and Regenerative Medicine·Nazish AhmedRita A Kandel
Dec 19, 2002·International Reviews of Immunology·Veijo HukkanenJuha-Pekka Erälinna
Oct 13, 2006·Current Opinion in Infectious Diseases·J D Kriesel
Jun 20, 2003·Current Eye Research·Patric Lundberg, Edouard Cantin
Jul 9, 2020·Nature Communications·Lívia H YamashiroRussell E Vance
Apr 16, 2018·Neuronal Signaling·Laura K OlsenDeclan P McKernan
Jun 8, 2001·Experimental Biology and Medicine·D J CarrB M Gebhardt

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved