Cytokine and CXC chemokine expression patterns in aqueous humor of patients with presumed tuberculous uveitis

Cytokine
Ahmed M Abu El-AsrarJo Van Damme

Abstract

Aqueous humor (AH) samples from 14 patients with presumed tuberculous uveitis (PTU), and 30 control patients were assayed for the proinflammatory cytokines interleukin IL-4, IL-12, IL-15, IL-17, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α, the immunosuppressive cytokine IL-10, and the chemokines GRO-α/CXCL1, IL-8/CXCL8, MIG/CXCL9, IP-10/CXCL10 and SDF-1/CXCL12 with the use of a multiplex assay. Among cytokines, IL-4 and IL-12 were not detected. IL-15, IL-17, IFN-γ, TNF-α and IL-10 levels in AH were significantly higher in patients than in controls (p<0.001; p=0.004; p<0.001; p<0.001; p<0.001, respectively). Among chemokines, SDF-1 levels did not differ significantly between patients and controls, whereas GRO-α, IL-8, MIG and IP-10 levels were significantly higher in patients than in controls (p=0.001; p<0.001; p<0.001; p<0.001, respectively). Mean GRO-α levels in AH of PTU patients were 6-fold higher than IL-8 levels and mean IP-10 levels were 15-fold higher than MIG levels. Clinical disease activity correlated significantly with the levels of IL-15, IFN-γ, TNF-α and IP-10. Logistic regression analysis demonstrated a significant positive association between PTU and high levels of IFN-γ, IL-8, MIG and IP-10. These data...Continue Reading

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Citations

Aug 10, 2013·BMC Ophthalmology·Stephen C Teoh, Andrew D Dick
Sep 1, 2015·Clinical & Experimental Ophthalmology·RuiPing GuGeZhi Xu
Jul 29, 2016·Ocular Immunology and Inflammation·Ravi K SharmaNaresh Sachdeva
Nov 23, 2016·Acta Ophthalmologica·Ester CarreñoAmalia Enríquez-de-Salamanca
Jul 9, 2014·The British Journal of Ophthalmology·Marcus AngSoon-Phaik Chee
May 8, 2018·Immunological Investigations·Ravi Kumar SharmaNaresh Sachdeva
Sep 14, 2018·Journal of Ophthalmic Inflammation and Infection·Aniruddha AgarwalVishali Gupta
Nov 18, 2020·Tuberculosis·Rupesh AgrawalCarlos Pavesio
Apr 17, 2021·Clinical Ophthalmology·Moustafa S MagliyahHassan Al-Dhibi

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