Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammation

American Journal of Respiratory Cell and Molecular Biology
Y OhkawaraM Jordana

Abstract

Selective accumulation of eosinophils and activated CD4+ cells is now considered a central event in the pathogenesis of asthma, and this process is thought to be mediated by a number of cytokines including tumor necrosis factor-alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), and the Type 2 cytokines interleukin-4 (IL-4) and IL-5. To carry out a detailed time-course analysis of cellular changes in the bronchoalveolar lavage fluid (BAL), peripheral blood (PB), and bone marrow (BM), and of changes in the aforementioned cytokines in BAL and serum, Balb/c mice were sensitized by intraperitoneal injection with ovalbumin (OVA) adsorbed to aluminum hydroxide on two occasions 5 days apart, and were subjected to an OVA aerosol challenge 12 days after the second sensitization. This resulted in an airways inflammatory response characterized by early transient neutrophilia, marked eosinophilia, and, to a lesser extent, lymphocytosis in the BAL. Inflammatory events were first observed 3 h and 24 h after antigen challenge in the lung tissue and BAL, respectively, and lasted for 21 days. In the BM, we detected a 1.5- and 5-fold increase in the total number of cells and eosinophils, respectively, 4 days after the s...Continue Reading

Citations

Jan 15, 2004·American Journal of Respiratory Medicine : Drugs, Devices, and Other Interventions·Ajay GautamCharles L Densmore
Aug 9, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Yan ShiXiaohong Lv
Oct 13, 1998·The Journal of Allergy and Clinical Immunology·R L MillerP Rothman
Aug 7, 2002·Pharmacology & Therapeutics·Adrian J BaatjesJudah A Denburg
Feb 20, 2003·Human Immunology·Carmela Di SommaAnna Ruffilli
Apr 6, 2004·Immunology and Allergy Clinics of North America·Judah A Denburg, Paul K Keith
Jan 6, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Mary Beth HoganKenneth S Landreth
Dec 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·G HalldénJ Lundahl
Jan 20, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I LalaniA R Ahmed
Jul 10, 2003·Pulmonary Pharmacology & Therapeutics·J SpondM Minnicozzi
Aug 14, 1999·Scandinavian Journal of Immunology·A MoshfeghJ Lundahl
Mar 5, 2008·The Journal of Experimental Medicine·Elizabeth A JacobsenJames J Lee
Mar 5, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·Eric R SecorRoger S Thrall
Sep 3, 2013·International Journal of Rheumatic Diseases·Naomi SuzukiTakashi Sawai
Oct 5, 2010·American Journal of Physiology. Lung Cellular and Molecular Physiology·Elizabeth KleinSandra M Wells
Aug 17, 2005·International Archives of Allergy and Immunology·Yasushi OhkiAkihiro Morikawa
Jul 26, 2006·International Archives of Allergy and Immunology·Filip K SwirskiMartin R Stämpfli
Mar 10, 2007·International Archives of Allergy and Immunology·Hiroo MayuzumiAkihiro Morikawa
Nov 16, 2007·International Archives of Allergy and Immunology·Wataru ItoArihiko Kanehiro
Apr 14, 2000·American Journal of Respiratory and Critical Care Medicine·P G KnottC P Bertrand
Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·S FukuyamaN Hara
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·A TomkinsonE W Gelfand
Jan 10, 2002·American Journal of Respiratory and Critical Care Medicine·C L Ordoñez, J V Fahy
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·J V Fahy
Dec 14, 2002·American Journal of Respiratory and Critical Care Medicine·Akira KoaraiHiroshi Ohtsu
Mar 5, 2003·American Journal of Respiratory and Critical Care Medicine·Charles L HardyRobyn E O'Hehir
May 10, 2005·American Journal of Respiratory and Critical Care Medicine·Karim Vermaelen, Romain Pauwels
May 10, 2005·American Journal of Respiratory and Critical Care Medicine·Ramzi FattouhManel Jordana
Feb 4, 2006·American Journal of Respiratory and Critical Care Medicine·Yoshihiko ChibaShioko Kimura
Jan 5, 2008·American Journal of Respiratory and Critical Care Medicine·Ramzi FattouhManel Jordana
Aug 3, 2002·American Journal of Respiratory and Critical Care Medicine·Gang ChengTakeshi Fukuda
Sep 17, 2002·American Journal of Respiratory and Critical Care Medicine·Lorna J WoodPaul M O'Byrne
Aug 26, 1999·American Journal of Respiratory Cell and Molecular Biology·E SalikK Sperber
Aug 26, 1999·American Journal of Respiratory Cell and Molecular Biology·M R StämpfliM Jordana

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