PMID: 9179627Feb 1, 1997Paper

Cytokine and nitric oxide production in the acute phase of bacterial cell wall-induced arthritis

Inflammation
J W FuselerM B Grisham

Abstract

We have investigated the temporal relationship among proinflammatory cytokine expression, nitric oxide (NO) production and joint inflammation in the acute phase of bacterial cell wall-derived peptidoglycan polysaccharide (PG/PS)-induced arthritis. Acute joint inflammation was induced in female LEW/N rats by a single intraperitoneal injection of PG/PS. Arthritis index and paw volume were quantified and joint histopathology was evaluated during acute joint inflammation (0-10 days). Tumor necrosis factor (TNF), interleukin-1 (IL-1) and interleukin-6 (IL-6) were determined by bioassay whereas nitric oxide (NO) was quantified by measuring serum nitrate/nitrite levels via the Griess procedure. We found that serum levels of TNF and serum IL-1 preceded the increase in IL-6 and NO production. Furthermore, the production of these proinflammatory cytokines and NO preceded bone erosion and osteoclast activity. Erosion of subchondral bone preceded pannus formation and cellular synovitis in the acute phase of PG/PS-induced arthritis. The temporal expression of TNF, IL-1, IL-6 and NO suggest a cascade of inflammatory mediators in which monocytes and macrophages respond to PG/PS with enhanced synthesis of TNF and IL-1, which may in turn promot...Continue Reading

Citations

Jun 12, 1999·Arthritis and Rheumatism·N L McCartney-FrancisS M Wahl
Oct 1, 2009·Korean journal of anesthesiology·Jong Taek ParkDae Young Kang
Nov 7, 2019·International Journal of Molecular Sciences·José H TeixeiraSusana G Santos
Dec 16, 2003·Arthritis and Rheumatism·Donald KimpelMatthew Grisham
May 8, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Charles H HenryLarry M Wolford

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