Cytokine-associated emotional and cognitive disturbances in humans

Archives of General Psychiatry
A ReichenbergT Pollmächer

Abstract

Infectious, autoimmune, and neurodegenerative diseases are associated with profound psychological disturbances. Studies in animals clearly demonstrate that cytokines mediate illness-associated behavioral changes. However, the mechanisms underlying the respective psychological alterations in humans have not been established yet. Therefore, we investigated the effects of low-dose endotoxemia, a well-established and safe model of host-defense activation, on emotional, cognitive, immunological, and endocrine parameters. In a double-blind, crossover study, 20 healthy male volunteers completed psychological questionnaires and neuropsychological tests 1, 3, and 9 hours after intravenous injection of Salmonella abortus equi endotoxin (0.8 ng/kg) or saline in 2 experimental sessions. Blood samples were collected hourly, and rectal temperature and heart rate were monitored continuously. Endotoxin had no effects on physical sickness symptoms, blood pressure, or heart rate. Endotoxin caused a mild increase in rectal temperature (0.5 degrees C), and increased the circulating levels of tumor necrosis factor alpha (TNF-alpha), soluble TNF receptors, interleukin (IL)-6, IL-1 receptor antagonist, and cortisol. After endotoxin administration, th...Continue Reading

Citations

Aug 9, 2002·European Journal of Heart Failure·Alan B Miller
Jun 1, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yuji KajiwaraJoseph D Buxbaum
Sep 3, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Timothy J Schoenfeld, Heather A Cameron
May 21, 2010·Neurological Research·Lingli YangLingjiang Li
May 17, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Giovanni ZulianiAntonio Cherubini
Jan 16, 2014·Journal of Physiological Anthropology·Eva M SelhubAlison C Bested
Feb 1, 2014·Neuroscience and Biobehavioral Reviews·Rosebella Alungata IsemeFrederick Rohan Walker
Apr 3, 2013·Social Cognitive and Affective Neuroscience·Jennifer S KullmannElke R Gizewski
May 6, 2014·Trends in Pharmacological Sciences·Johannes KornhuberErich Gulbins
Aug 13, 2014·Nature Reviews. Clinical Oncology·Julienne E Bower
Jul 6, 2014·Neurochemical Research·Helena M AbelairaJoão Quevedo
Dec 14, 2002·Bipolar Disorders·Martin SchaeferMarkus Schwarz
Jan 19, 2013·Intensive Care Medicine·Annemiek E WoltersDiederik van Dijk
Jul 9, 2014·Brain, Behavior, and Immunity·Carissa A LowDavid L Bartlett
Jun 5, 2013·Proceedings of the National Academy of Sciences of the United States of America·Guang YangWen-Biao Gan
Nov 26, 2010·Nutrition Reviews·Saebyeol Jang, Rodney W Johnson
Dec 1, 2002·Acta Neuropsychiatrica·Hymie Anisman
Nov 3, 2010·The British Journal of Psychiatry : the Journal of Mental Science·Julie A PascoMichael Berk
Apr 25, 2012·Journal of Neurovirology·Thorsten NoltingUNKNOWN German Competence Network HIV/AIDS
Jul 12, 2007·Seminars in Immunopathology·Nadja TariverdianPetra C Arck
Oct 30, 2013·Disease Markers·Firoza MamdaniMarquis P Vawter
Nov 9, 2000·The Western Journal of Medicine·R Yirmiya
May 3, 2006·Archives of General Psychiatry·Raymond L OwnbyDavid Loewenstein
Jan 17, 2007·Journal of Neuroinflammation·Afina W LemstraWillem A van Gool
Feb 24, 2007·Nature Reviews. Cancer·Tim A Ahles, Andrew J Saykin
Jun 28, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Leonardo H TonelliTeodor T Postolache
Jun 14, 2008·Sleep & Breathing = Schlaf & Atmung·Alexander HaenselJoel E Dimsdale
Sep 11, 2008·Current Treatment Options in Neurology·Teodor T PostolacheLeonardo H Tonelli
May 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Leah M PyterBrian J Prendergast
Oct 23, 2009·PLoS Neglected Tropical Diseases·Courtney L OlsonJennifer F Friedman
Dec 10, 2009·Psychological Medicine·A R SutinP T Costa
Feb 26, 2010·Annals of Indian Academy of Neurology·Daniel Ontaneda, Alex D Rae-Grant
Feb 26, 2010·Biodemography and Social Biology·Noreen Goldman, Jennifer B Dowd
May 5, 2010·The Journal of Experimental Medicine·Noël C DereckiJonathan Kipnis
May 7, 2010·Critical Care : the Official Journal of the Critical Care Forum·Mark van den BoogaardPeter Pickkers
Jul 30, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Xiaohua Li, Richard S Jope
Feb 18, 2011·JAMA : the Journal of the American Medical Association·Golam M Khandaker, Peter B Jones

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Forebrain- Circuits

Basal forebrain is a region in the brain important for production of acetylcholine and is the major cholinergic output of the CNS. Discover the latest research on circuits in the basal forebrain here.

Related Papers

Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer
Masatoshi InagakiYosuke Uchitomi
Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Mara M EpsteinBrenda M Birmann
© 2021 Meta ULC. All rights reserved