Cytokine BAFF gene variation is associated with survival of patients with T-cell lymphomas

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Kan ZhaiDongxin Lin

Abstract

Cytokine BAFF is a potent molecule for the activation and survival of B cells, and it also plays an important role in T-cell function. Genetic polymorphism (rs9514828C>T) in BAFF has been associated with elevated BAFF transcription. We sought to determine whether rs9514828 is associated with T-cell lymphoma (TCL) survival. BAFF rs9514828 genotypes and survival of TCL were analyzed in the discovery group including 150 patients, and the results were replicated in an independent validation group of 120 patients. Kaplan-Meier analysis was conducted to compare survival among different genotypes. Cox proportional hazard models were used to identify independent significant variables. Luciferase reporter gene assays were conducted to examine the function of rs9514828 variant. We found that BAFF rs9514828 polymorphism was significantly associated with TCL survival. In pooled analysis of two independent groups, the favorable rs9514828 TC and TT genotypes had significantly better five-year survival rates compared with the CC genotype (47% and 53% vs. 22%, P = 2.27 × 10(-5) for log-rank test). Multivariate Cox regression analysis showed that rs9514828 was an independent prognostic factor, with HRs for patient death being 0.48 [95% confiden...Continue Reading

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Citations

Jul 4, 2012·Journal of Autoimmunity·Ayan LahiriJacques-Olivier Pers
Jul 13, 2013·Journal of Autoimmunity·Adrianos NezosClio P Mavragani
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Dec 20, 2020·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Nikolaos-Panagiotis AndreouMaria Gazouli

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