Cytokine-based immune monitoring

Clinical Biochemistry
O Millán, Mercè Brunet

Abstract

Several studies conducted during the last decade have shown that some promising biomarkers and surrogate markers may be useful in implementing personalized immunomodulatory therapies and improving graft and recipient care in solid organ transplantation. The complexity of the immune system response against the implanted graft can change remarkably in the long-term follow-up, and the dynamic balance between T-effector/T-regulatory cell populations determines the outcome of the anti-donor response, risk of rejection, and immunosuppression requirements. For this reason, at any time before and after transplantation, monitoring the T-effector cell activity, associated with an increase in pro-inflammatory cytokine production and release, can be considered as a surrogate marker of the risk of rejection and immunosuppression requirements. Furthermore, infections remain a cause of major complications following transplantation, highlighting the need for developing new approaches aimed at identifying the risk of infection in solid organ recipients. Another main aspect to be considered is that immunosuppressive agents may immunomodulate each treated patient differently. Immunosuppressive drugs show high pharmacokinetic and pharmacodynamic i...Continue Reading

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Citations

May 3, 2019·Therapeutic Drug Monitoring·Mercè BrunetStein Bergan
Nov 17, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Haibo FengJie Yang
May 18, 2018·BMC Gastroenterology·Imeke GoldschmidtUlrich Baumann
Nov 6, 2018·Frontiers in Immunology·Chloé Albert-VegaJulien Textoris
Oct 2, 2020·Scientific Reports·Chloé Albert VegaSophie Trouillet-Assant
Nov 29, 2020·Endocrine Reviews·Braulio A Marfil-GarzaA M James Shapiro

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