Cytokine, chemokine and BDNF levels in medication-free pediatric patients with obsessive-compulsive disorder

European Child & Adolescent Psychiatry
Rukiye Çolak Sivriİbrahim Kılınç

Abstract

The aim of this study was to investigate whether the serum levels of IL-12, IL-17, TGFβ, TNF-alpha, sTNFR1, sTNFR2, IL-1β, CCL3, CCL24, CXCL8, and BDNF are associated with obsessive-compulsive disorder (OCD) in medication-free children. A total of 44 (22 boys/22 girls) medication-free children with OCD and 40 (23 boys/17 girls) healthy controls were included in this study. The severity of the OCD symptoms were assessed by the Children's Yale-Brown Obsessive-Compulsive Scale and the Maudsley Obsessive-Compulsive Inventory. The Children's Depression Inventory and the Screen for Child Anxiety-Related Emotional Disorders were applied to the children in order to determine depression and anxiety levels. IL-17, IL-12, TGF β, TNF-alpha, sTNFR1, sTNFR2, IL-1β, CCL3, CCL24, CXCL8, and BDNF levels were measured by enzyme-linked immunosorbent assay. Multivariate analysis of covariance (MANCOVA) revealed a significant main effect on both groups for the levels of serum cytokine, chemokine, and BDNF, an effect that was independent of severities of depression and anxiety [Pillai's Trace V = 0.371, F (11, 70) = 3.756, p < 0.001, hp2 = 0.187]. Analysis of covariance (ANCOVA) indicated that serum TNF-alpha levels were significantly higher in the ...Continue Reading

References

Mar 24, 1999·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M MaesS Scharpé
Oct 12, 1999·Journal of the American Academy of Child and Adolescent Psychiatry·B BirmaherM Baugher
Apr 28, 2000·The American Journal of Psychiatry·Z Kronfol, D G Remick
Mar 17, 2001·Microbes and Infection·X Ma
Aug 25, 2001·Annual Review of Neuroscience·E J Huang, L F Reichardt
Dec 6, 2002·The International Journal of Neuropsychopharmacology·Gunter Kenis, Michael Maes
Jun 5, 2004·Psychoneuroendocrinology·Damiaan DenysHerman Westenberg
Mar 23, 2005·Biological Psychiatry·James F LeckmanRobert A King
Jan 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Andrea DaneseRichie Poulton
Feb 16, 2007·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Haiqun LinJames F Leckman
Feb 12, 2008·Progress in Neuro-psychopharmacology & Biological Psychiatry·Felipe Filardi da RochaAntonio Lucio Teixeira
May 12, 2009·Progress in Neuro-psychopharmacology & Biological Psychiatry·Vilma GabbayCharles J Gonzalez
Aug 12, 2009·Journal of Affective Disorders·Giuseppe MainaLuisella Bocchio-Chiavetto
Sep 8, 2009·Journal of Neuroimmunology·Paula ScalzoAntônio Lúcio Teixeira
May 7, 2010·European Archives of Psychiatry and Clinical Neuroscience·Izabela Guimarães BarbosaAntônio Lúcio Teixeira
Jul 6, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Netty G P Bos-VenemanPieter J Hoekstra
Feb 11, 2011·Current Infectious Disease Reports·Sheila Knupp Feitosa de Oliveira, Christina Feitosa Pelajo
Sep 29, 2011·Psychosomatic Medicine·Emma Robertson BlackmoreThomas G O'Connor
Feb 4, 2012·Comprehensive Psychiatry·Leonardo F FontenelleAntonio Lucio Teixeira
Apr 5, 2012·BMC Psychiatry·Judith MatzNorbert Müller
Apr 6, 2012·Current Psychiatry Reports·Simon M Gray, Michael H Bloch
Apr 13, 2012·Psychiatry Research·Leonardo F FontenelleAntonio Lucio Teixeira
Dec 5, 2012·European Child & Adolescent Psychiatry·Per Hove Thomsen
Jun 22, 2013·Child and Adolescent Psychiatry and Mental Health·Rajshekhar BipetaMohammad Osman Ali
Sep 26, 2013·Molecular Biology Reports·Dorota FrydeckaAndrzej Kiejna
Feb 22, 2012·World Journal of Psychiatry·Carlo FaravelliValdo Ricca
Feb 26, 2014·Journal of the American Academy of Child and Adolescent Psychiatry·Rachel H B Mitchell, Benjamin I Goldstein
May 22, 2016·The International Journal of Neuropsychopharmacology·Şeref ŞimşekSavaş Kaya
Sep 22, 2016·Schizophrenia Research·Suzi HongDilip V Jeste
Oct 21, 2016·Psychiatry Investigation·Damla TokacCem Ismail Kucukali

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Citations

Nov 2, 2018·Molecular Neurobiology·Theodore D CoscoAndre F Carvalho
Aug 12, 2018·Brain Sciences·Hugues LamotheLuc Mallet
Nov 18, 2020·Child and Adolescent Mental Health·Chelsea ParsonsNatalie T Mills
Feb 2, 2021·CNS Spectrums·Giacomo GrassiLuisa Vignozzi
Mar 24, 2021·Nordic Journal of Psychiatry·Bürge Kabukçu BaşaySezai Üstün Aydin
Apr 5, 2021·Journal of Psychiatric Research·Manjula SubbannaJanardhanan C Narayanaswamy

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