Cytokine-Defined B Cell Responses as Therapeutic Targets in Multiple Sclerosis

Frontiers in Immunology
Rui LiMSSRF Canadian B cells in MS Team

Abstract

Important antibody-independent pathogenic roles of B cells are emerging in autoimmune diseases, including multiple sclerosis (MS). The contrasting results of different treatments targeting B cells in patients (in spite of predictions of therapeutic benefits from animal models) call for a better understanding of the multiple roles that distinct human B cell responses likely play in MS. In recent years, both murine and human B cells have been identified with distinct functional properties related to their expression of particular cytokines. These have included regulatory (Breg) B cells (secreting interleukin (IL)-10 or IL-35) and pro-inflammatory B cells (secreting tumor necrosis factor α, LTα, IL-6, and granulocyte macrophage colony-stimulating factor). Better understanding of human cytokine-defined B cell responses is necessary in both health and diseases, such as MS. Investigation of their surface phenotype, distinct functions, and the mechanisms of regulation (both cell intrinsic and cell extrinsic) may help develop effective treatments that are more selective and safe. In this review, we focus on mechanisms by which cytokine-defined B cells contribute to the peripheral immune cascades that are thought to underlie MS relapses...Continue Reading

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Citations

Nov 9, 2016·Frontiers in Immunology·Meike Mitsdoerffer, Anneli Peters
Mar 27, 2018·International Journal of Cancer. Journal International Du Cancer·Manouchehr TeymouriAmirhosein Sahebkar
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Mar 10, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rui LiUNKNOWN Canadian B Cells in MS Team
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May 5, 2021·Biomedical Materials·Arvind Manikantan PadmaMats Hellström
Aug 13, 2021·Journal of Neurology·Monica MargoniMaria A Rocca

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