PMID: 8610985Feb 13, 1996Paper

Cytokine-dependent modulation of oral tolerance in a murine model of autoimmune uveitis

Annals of the New York Academy of Sciences
R R CaspiL V Rizzo

Abstract

In summary, our data suggest that oral tolerance in the mouse EAU model may occur by anergy/deletion or by suppression, depending on the feeding regimen. Tolerance involving putative regulatory cells appears to require the ability to produce both IL-4 and IL-10, whereas induction of tolerance involving anergy may not require the presence of Il-4 and IL-10. We propose that regulatory cells induced by three feedings of IRBP can be selectively enhanced through the use of cytokines. From the point of view of clinical therapy, it would be worthwhile to explore postimmunization feeding regimens involving administration of IL-4 and IL-10.

References

Apr 15, 1992·The Journal of Immunology : Official Journal of the American Association of Immunologists·R R CaspiB Wiggert
Jan 1, 1990·Current Eye Research·R R CaspiG J Chader
Jun 1, 1990·Journal of Autoimmunity·C C ChanR B Nussenblatt
Dec 1, 1994·The Journal of Allergy and Clinical Immunology·R A Seder
Jan 1, 1994·Annual Review of Immunology·R A Seder, W E Paul
Oct 1, 1994·The Journal of Clinical Investigation·L V RizzoR R Caspi

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Citations

Jan 1, 1996·Immunologic Research·V K Singh, K Nagaraju
Jun 6, 2000·Advanced Drug Delivery Reviews·J W Simecka
Jan 29, 2000·Immunology and Cell Biology·J ChinA Mullbacher
Jan 29, 2008·Journal of Pediatric Gastroenterology and Nutrition·Folashade A Jose, Melvin B Heyman
Nov 5, 1997·Clinical Immunology and Immunopathology·B G Xiao, H Link
Oct 27, 2004·Journal of Autoimmunity·Patricia A GonnellaHoward L Weiner
Mar 12, 2004·Annual Review of Psychology·R J MacCoun
Jul 7, 2007·Ocular Immunology and Inflammation·Andrew W TaylorJ Wayne Streilein
Dec 17, 2014·Pain Management·Corey W WaldmanReid A Waldman

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