Cytokine-directed therapies in multiple sclerosis and experimental autoimmune encephalomyelitis

Immunology and Cell Biology
S R Ruuls, Jonathon D Sedgwick

Abstract

Secreted and cell surface molecules that control the nature of immune responses or directly mediate tissue damage are important targets for therapeutic intervention of autoimmune inflammatory disorders. The precise aetiology of multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system is unknown and therapeutic interventions for this disease are limited. However, as it is believed that MS is autoimmune in nature, it seems likely that targeting of the immune system, either to deviate it down a more benign pathway or to directly block tissue damaging effector mechanisms, may enable this disease to be controlled. In this overview we examine three alternative approaches to therapy of MS: cytokine-directed immune deviation, immunoregulation by type I interferons and blockade of TNF. Underlying rationales for the application of these approaches to the treatment of MS are based largely on studies in the disease model experimental autoimmune encephalomyelitis. These studies are reviewed.

References

Aug 1, 1992·Trends in Neurosciences·D J SloanH M Charlton
Jun 1, 1992·Journal of Interferon Research·A T Reder, M T Lowy
Nov 1, 1991·Annals of Neurology·K SelmajA H Cross
Aug 15, 1991·The New England Journal of Medicine·M K Sharief, R Hentges
Mar 1, 1991·The Journal of Clinical Investigation·K SelmajC F Brosnan
Jan 1, 1990·Annual Review of Immunology·S S Zamvil, L Steinman
Apr 1, 1986·The Journal of Experimental Medicine·K InabaS Muramatsu
Dec 1, 1989·The Journal of Experimental Medicine·D F FiorentinoT R Mosmann
Jan 1, 1988·Journal of Steroid Biochemistry·P M GuyreP D Manganiello
Apr 1, 1988·Annals of Neurology·K W Selmaj, C S Raine
Oct 1, 1986·Journal of Neuroimmunology·J RoosthW J Meyer
Jan 1, 1982·Immunological Communications·S L Abreu
Nov 21, 1995·Proceedings of the National Academy of Sciences of the United States of America·L ProbertG Kollias
Jun 1, 1994·European Journal of Immunology·O RottE Cash
Nov 1, 1994·The Journal of Experimental Medicine·M K RackeM Röcken
Jan 1, 1995·The Journal of Experimental Medicine·J P LeonardS J Goldman
Aug 1, 1995·Immunology Today·A Kelso
Jul 1, 1995·Neurology·P G Fisher, H S Singer

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Citations

Apr 29, 1998·Immunology and Cell Biology·C R ParishD O Willenborg
Aug 6, 2004·The Pediatric Infectious Disease Journal·John A D LeakeJohn S Bradley
Sep 13, 2011·Current Opinion in Immunology·Burkhard Becher, Benjamin M Segal
Sep 22, 2007·Human & Experimental Toxicology·María J NúñezManuel Freire-Garabal

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